N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide

Base Information

Chemical Name:N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide
CAS No.:133229-35-3
Molecular Formula:C₁₈H₂₃ClN₂O₄S
Molecular Weight:398.911
Hs Code.:

Synonyms:N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide

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Chemical Property of N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide

Chemical Property:

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Technology Process of N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide

There total 5 articles about N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 133229-35-3
N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1 N NaOH / 10 h

2: ethanol / 4 h / Heating

3: p-toluenesulfonic acid / toluene / 16 h / Heating

4: H₂, 2 N NaOH / 10percent Pd/C / ethanol / 0.25 h / 760 Torr

5: 2.) 1 N HCl / 1.) ether, from 10 deg C to RT, 12 h, 2.) 1 h

With hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00109a007

Reference yield:

: 125228-75-3
4-nitrophenyl 2-oxiranylmethyl ether

: 133229-35-3
N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: ethanol / 4 h / Heating

2: p-toluenesulfonic acid / toluene / 16 h / Heating

3: H₂, 2 N NaOH / 10percent Pd/C / ethanol / 0.25 h / 760 Torr

4: 2.) 1 N HCl / 1.) ether, from 10 deg C to RT, 12 h, 2.) 1 h

With hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00109a007

Reference yield:

: 133228-97-4
1-[2-(4-Chloro-phenyl)-ethylamino]-3-(4-nitro-phenoxy)-propan-2-ol

: 133229-35-3
N-(4-{3-[2-(4-Chloro-phenyl)-ethylamino]-2-hydroxy-propoxy}-phenyl)-methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: p-toluenesulfonic acid / toluene / 16 h / Heating

2: H₂, 2 N NaOH / 10percent Pd/C / ethanol / 0.25 h / 760 Torr

3: 2.) 1 N HCl / 1.) ether, from 10 deg C to RT, 12 h, 2.) 1 h

With hydrogenchloride; sodium hydroxide; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In ethanol; toluene;
DOI:10.1021/jm00109a007