(R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine

Base Information

Chemical Name:(R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine
CAS No.:209161-36-4
Molecular Formula:C₂₀H₃₄N₂O₂
Molecular Weight:334.502
Hs Code.:

Synonyms:(R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine

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Technology Process of (R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine

There total 5 articles about (R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 50.0%

: 1-((4S,5S)-5-{1-[(E)-Hydroxyimino]-2-phenyl-ethyl}-2,2-dimethyl-[1,3]dioxolan-4-yl)-heptan-1-one oxime

: 209161-36-4
(R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine

Guidance literature:: With diisobutylaluminium hydride; In toluene; at 0 - 25 ℃; for 18h;
DOI:10.1016/S0960-894X(98)00175-9

Reference yield:

: 3761-92-0
n-hexylmagnesium bromide

: 209161-36-4
(R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 2.) aq. H₂NOH*HCl / 1.) THF, 0 deg C, 3 h, 2.) EtOH, 18 h

2: 50 percent / DIBAL / toluene / 18 h / 0 - 25 °C

With hydroxylamine hydrochloride; diisobutylaluminium hydride; In toluene;
DOI:10.1016/S0960-894X(98)00175-9

Reference yield:

: 177283-77-1
(4R,5R)-N,N'-dimethoxy-N,N',2,2-tetramethyl-1,3-dioxolane-4,5-dicarboxamide

: 209161-36-4
(R)-1-[(4S,5S)-5-((R)-1-Amino-2-phenyl-ethyl)-2,2-dimethyl-[1,3]dioxolan-4-yl]-heptylamine

Guidance literature:: Multi-step reaction with 3 steps

1: 2.) aq. H₂NOH*HCl / 1.) THF, from -78 deg C to 0 deg C, 3 h, 2.) EtOH, 18 h

2: 2.) aq. H₂NOH*HCl / 1.) THF, 0 deg C, 3 h, 2.) EtOH, 18 h

3: 50 percent / DIBAL / toluene / 18 h / 0 - 25 °C

With hydroxylamine hydrochloride; diisobutylaluminium hydride; In toluene;
DOI:10.1016/S0960-894X(98)00175-9