3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

Base Information

Chemical Name:3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester
CAS No.:1248336-23-3
Molecular Formula:C₂₆H₃₉F₃N₄O₇
Molecular Weight:576.613
Hs Code.:

Synonyms:3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

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Chemical Property of 3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

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Technology Process of 3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

There total 3 articles about 3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 1248336-22-2
N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

: 1248336-23-3
3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

Guidance literature:: With hydroxylamine hydrochloride; In dichloromethane; at 45 ℃; for 1h;
DOI:10.1074/jbc.M110.104547

Reference yield:

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 1248336-23-3
3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide / dichloromethane / -78 °C

2: hydroxylamine hydrochloride / dichloromethane / 1 h / 45 °C

With hydroxylamine hydrochloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane;
DOI:10.1074/jbc.M110.104547

Reference yield:

: 299931-15-0
2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl bromide

: 1248336-23-3
3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide / dichloromethane / -78 °C

2: hydroxylamine hydrochloride / dichloromethane / 1 h / 45 °C

With hydroxylamine hydrochloride; 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane;
DOI:10.1074/jbc.M110.104547