N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

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Chemical Name:N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester
CAS No.:1248336-22-2
Molecular Formula:C₃₉H₄₇F₃N₄O₇
Molecular Weight:740.82
Hs Code.:

N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

Synonyms:N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

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Chemical Property of N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

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Technology Process of N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

There total 1 articles about N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 81477-94-3
N-(diphenylmethylene)glycine tert-butyl ester

: 299931-15-0
2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]benzyl bromide

: 1248336-22-2
N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

Guidance literature:: With 2-tert-butylimino-2-diethylamino-1,3-dimethyl-perhydro-1,3,2-diazaphosphorine; (2S,4S,5R)-1-(anthracen-9-ylmethyl)-5-ethenyl-2-[(R)-(prop-2-en-1-yloxy)(quinolin-4-yl)methyl]-1-azabicyclo[2.2.2]octan-1-ium bromide; In dichloromethane; at -78 ℃;
DOI:10.1074/jbc.M110.104547

Reference yield: 92.0%

: 1248336-22-2
N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

: 1248336-23-3
3-[2-[2-[2-(2-(tert-butoxycarbonylamino)ethoxy)ethoxy]-ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alaninetert-butyl ester

Guidance literature:: With hydroxylamine hydrochloride; In dichloromethane; at 45 ℃; for 1h;
DOI:10.1074/jbc.M110.104547

Reference yield:

: 1248336-22-2
N-(diphenylmethylene)-3-[2-[2-[2-(2-tert-butoxycarbonylaminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]phenyl]-L-alanine tert-butyl ester

: N-palmitoyl-3-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]-4-[3-(trifluoromethyl)-3H-diazirin-3-yl]-phenylalanine

Guidance literature:: Multi-step reaction with 3 steps

1: hydroxylamine hydrochloride / dichloromethane / 1 h / 45 °C

2: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine / dichloromethane / 20 °C

3: trifluoroacetic acid / chloroform / 20 °C

With hydroxylamine hydrochloride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; triethylamine; trifluoroacetic acid; In dichloromethane; chloroform;
DOI:10.1074/jbc.M110.104547