methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Base Information

Chemical Name:methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate
CAS No.:1332707-10-4
Molecular Formula:C₂₇H₂₄F₂N₂O₃
Molecular Weight:462.496
Hs Code.:

Synonyms:methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

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Chemical Property of methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

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Technology Process of methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

There total 12 articles about methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332707-09-1
methyl 3-{[5-(biphenyl-4-yl)-1-(biphenyl-4-ylmethyl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

: 1332707-10-4
methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: With ethanol; cyclohexa-1,4-diene; 10 wt% Pd(OH)2 on carbon; In ethyl acetate; at 120 ℃; for 1.5h; microwave irradiation;

Reference yield:

: 16205-98-4
3-oxo-cyclohexanecarboxylic acid

: 1332707-10-4
methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 5 steps

1: thionyl chloride / 3 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 0 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 120 °C / Inert atmosphere

5: cyclohexa-1,4-diene; ethanol / 10 wt% Pd(OH)2 on carbon / ethyl acetate / 1.5 h / 120 °C / microwave irradiation

With sodium tetrahydroborate; thionyl chloride; ethanol; cyclohexa-1,4-diene; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 21531-47-5,49543-02-4,13148-83-9,1236384-30-7
3-oxo-cyclohexanecarboxylic acid methyl ester

: 1332707-10-4
methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: sodium tetrahydroborate / methanol / 2 h / 0 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 120 °C / Inert atmosphere

4: cyclohexa-1,4-diene; ethanol / 10 wt% Pd(OH)2 on carbon / ethyl acetate / 1.5 h / 120 °C / microwave irradiation

With sodium tetrahydroborate; ethanol; cyclohexa-1,4-diene; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; In methanol; water; ethyl acetate; N,N-dimethyl-formamide;