3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Base Information

Chemical Name:3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid
CAS No.:1332706-77-0
Molecular Formula:C₂₆H₂₂F₂N₂O₃
Molecular Weight:448.469
Hs Code.:

Synonyms:3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

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Chemical Property of 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

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Technology Process of 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

There total 13 articles about 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1332707-10-4
methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate

: 1332706-77-0
3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Guidance literature:: methyl 3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylate; With potassium trimethylsilonate; In tetrahydrofuran; at 20 ℃;

With hydrogenchloride; In water;

Reference yield:

: 16205-98-4
3-oxo-cyclohexanecarboxylic acid

: 1332706-77-0
3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 6 steps

1: thionyl chloride / 3 h / 20 °C

2: sodium tetrahydroborate / methanol / 2 h / 0 °C / Inert atmosphere

3: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

4: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 120 °C / Inert atmosphere

5: cyclohexa-1,4-diene; ethanol / 10 wt% Pd(OH)2 on carbon / ethyl acetate / 1.5 h / 120 °C / microwave irradiation

6: potassium trimethylsilonate / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; thionyl chloride; ethanol; cyclohexa-1,4-diene; potassium trimethylsilonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;

Reference yield:

: 21531-47-5,49543-02-4,13148-83-9,1236384-30-7
3-oxo-cyclohexanecarboxylic acid methyl ester

: 1332706-77-0
3-{[5-(biphenyl-4-yl)-4,6-difluoro-1H-benzimidazol-2-yl]oxy}cyclohexanecarboxylic acid

Guidance literature:: Multi-step reaction with 5 steps

1: sodium tetrahydroborate / methanol / 2 h / 0 °C / Inert atmosphere

2: 1,8-diazabicyclo[5.4.0]undec-7-ene / N,N-dimethyl-formamide / 80 °C

3: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide; water / 1 h / 120 °C / Inert atmosphere

4: cyclohexa-1,4-diene; ethanol / 10 wt% Pd(OH)2 on carbon / ethyl acetate / 1.5 h / 120 °C / microwave irradiation

5: potassium trimethylsilonate / tetrahydrofuran / 20 °C

With sodium tetrahydroborate; ethanol; cyclohexa-1,4-diene; potassium trimethylsilonate; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 wt% Pd(OH)2 on carbon; In tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;