1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

Base Information

Chemical Name:1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole
CAS No.:1219741-26-0
Molecular Formula:C₂₁H₁₅F₂IN₂O₂S
Molecular Weight:524.33
Hs Code.:

Synonyms:1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

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Chemical Property of 1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

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Technology Process of 1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

There total 7 articles about 1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1219741-32-8
1-(biphenyl-4-ylmethyl)-4,6-difluoro-5-iodo-2-(methylthio)-1H-benzimidazole

: 1219741-26-0
1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

Guidance literature:: With 3-chloro-benzenecarboperoxoic acid; In dichloromethane; at 20 ℃; for 17h;

Reference yield:

: 712-76-5
N-(4-phenyl)benzylamine

: 1219741-26-0
1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / tetrahydrofuran / 15 h / 20 °C

2: acetic acid; N-iodo-succinimide / 2 h / 70 °C

3: acetic acid; iron / ethanol; water / 2 h / 76 °C

4: dimethyl sulfoxide / 16 h / 20 °C

5: caesium carbonate / tert-butyl methyl ether; tetrahydrofuran / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 17 h / 20 °C

With N-iodo-succinimide; iron; potassium carbonate; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; water; dimethyl sulfoxide;

Reference yield:

: 315-14-0
1,3,5-trifluoro-2-nitrobenzene

: 1219741-26-0
1-(biphenyl-4-ylmethyl)-4.6-difluoro-5-iodo-2-(methylsulfonyl)-1H-benzimidazole

Guidance literature:: Multi-step reaction with 6 steps

1: potassium carbonate / tetrahydrofuran / 15 h / 20 °C

2: acetic acid; N-iodo-succinimide / 2 h / 70 °C

3: acetic acid; iron / ethanol; water / 2 h / 76 °C

4: dimethyl sulfoxide / 16 h / 20 °C

5: caesium carbonate / tert-butyl methyl ether; tetrahydrofuran / 20 °C

6: 3-chloro-benzenecarboperoxoic acid / dichloromethane / 17 h / 20 °C

With N-iodo-succinimide; iron; potassium carbonate; caesium carbonate; acetic acid; 3-chloro-benzenecarboperoxoic acid; In tetrahydrofuran; ethanol; dichloromethane; tert-butyl methyl ether; water; dimethyl sulfoxide;