2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Base Information

• Chemical Name: 2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one
• CAS No.: 111751-28-1
• Molecular Formula: C₂₅H₂₂BrClN₂O₃
• Molecular Weight: 513.818

Synonyms:2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

Chemical Property of 2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

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Technology Process of 2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one

There total 3 articles about 2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 37.0%

2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid (111751-14-5) + (4-bromophenyl)hydrazine (589-21-9) → 2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one (111751-28-1)

Guidance literature:

In ethanol; for 3h; Heating;

DOI:10.1002/jhet.5570240114

Reference yield:

4-(p-chlorophenyl)-2-oxobutanoic acid (76400-21-0) → 2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one (111751-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / potassium hydroxide / H₂O / 48 h / 0 °C

2: 37 percent / ethanol / 3 h / Heating

With potassium hydroxide; In ethanol; water;

DOI:10.1002/jhet.5570240114

Reference yield:

1-(4-methoxyphenyl)ethanone (100-06-1) → 2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-4-hydroxy-6-(4-methoxy-phenyl)-4,5-dihydro-2H-pyridazin-3-one (111751-28-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 40 percent / potassium hydroxide / H₂O / 48 h / 0 °C

2: 37 percent / ethanol / 3 h / Heating

With potassium hydroxide; In ethanol; water;

DOI:10.1002/jhet.5570240114

upstream raw materials:

2-[2-(4-Chloro-phenyl)-ethyl]-2-hydroxy-4-(4-methoxy-phenyl)-4-oxo-butyric acid

(4-bromophenyl)hydrazine

4-(p-chlorophenyl)-2-oxobutanoic acid

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

2-(4-Bromo-phenyl)-4-[2-(4-chloro-phenyl)-ethyl]-6-(4-methoxy-phenyl)-2H-pyridazin-3-one

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