1-(2-Methoxyphenoxy)-2,3-epoxypropane

Base Information

• Chemical Name: 1-(2-Methoxyphenoxy)-2,3-epoxypropane
• CAS No.: 2210-74-4
• Molecular Formula: C10H12O3
• Molecular Weight: 180.203
• Hs Code.: 29109000
• European Community (EC) Number: 218-644-8
• NSC Number: 133442,112256
• UNII: Z96AT4ECV6
• DSSTox Substance ID: DTXSID601292484
• Nikkaji Number: J50.918C
• Mol file: 2210-74-4.mol

Synonyms:2210-74-4;1-(2-Methoxyphenoxy)-2,3-epoxypropane;Guaiacol glycidyl ether;2-[(2-methoxyphenoxy)methyl]oxirane;[(2-methoxyphenoxy)methyl]oxirane;2-((2-methoxyphenoxy)methyl)oxirane;Glycidyl 2-Methoxyphenyl Ether;1,2-Epoxy-3-(o-methoxyphenoxy)propane;1,2-Epoxy-3-(2-methoxyphenoxy)propane;Oxirane, [(2-methoxyphenoxy)methyl]-;Guajacol-glycidaether;NSC 133442;NSC 112256;Z96AT4ECV6;2-(2,3-Epoxypropoxy)anisole;Guajacol-glycidaether [German];((o-Methoxyphenoxy)methyl)oxirane;EINECS 218-644-8;MFCD00190158;NSC-112256;NSC-133442;Oxirane, ((2-methoxyphenoxy)methyl)-;BRN 0007199;Propane, 1,2-epoxy-3-(o-methoxyphenoxy)-;WLN: T3OTJ B1OR BO1;Propane,2-epoxy-3-(o-methoxyphenoxy)-;O-Methoxy phenyl cycloxypropylether;Oxirane,2-[(2-methoxyphenoxy)methyl]-;1-(2,3-Epoxypropoxy)-2-methoxybenzene;Glycidyl Guaiacol Ether;UNII-Z96AT4ECV6;SCHEMBL93244;Glycidyl(2-methoxyphenyl) ether;AMY8958;2-(2-methoxyphenoxymethyl)oxirane;DTXSID601292484;BCP22645;2-(2-Methoxy-phenoxymethyl)-oxirane;BBL011260;NSC112256;NSC133442;STK938910;GLYCIDYL O-METHOXYPHENYL ETHER;1-methoxy-2-(oxiranylmethoxy) benzene;AKOS000122885;AKOS016051052;2-Epoxy-1-(2-methoxyphenoxy)-propane;AC-5902;CS-W017203;DS-2271;1-(o-methoxy-phenoxy)-2,3-epoxypropane;1-(2-methoxy phenoxy)-2,3-epoxypropane;1-(2-methoxyphenyloxy)-2,3-epoxypropane;SY057927;1-(o-methoxy-phenoxy)-2,3-epoxy-propane;1-(2-methoxyphenyloxy)-2,3-epoxy-propane;LS-120800;2-METHOXY-1-(OXIRANYLMETHOXY)BENZENE;FT-0626817;FT-0671322;G0416;EN300-22424;A24914;EC 218-644-8;OXIRANE, 2-((2-METHOXYPHENOXY)METHYL)-;BENZENE, 1-(2,3-EPOXYPROPOXY)-2-METHOXY-;J-014505;J-523857;Z147642768;( inverted exclamation markA)-2-[(2-Methoxyphenoxy)methyl]oxirane;1,2-epoxy-3-(o-methoxyphenoxy)-propan;1,2-epoxy-3-(o-methoxyphenoxy)propane;3-(2-Methoxphenoxy)-1,2-epoxypropane;guajacol-glycidaether;2-[(2-Methoxyphenoxy)methyl]oxirane

Chemical Property of 1-(2-Methoxyphenoxy)-2,3-epoxypropane

Chemical Property:

• Appearance/Colour: White crystalline solid
• Vapor Pressure: 0.0152mmHg at 25°C
• Melting Point: 33-36 °C
• Refractive Index: 1.526
• Boiling Point: 265.3 °C at 760 mmHg
• Flash Point: 87.4 °C
• PSA: 30.99000
• Density: 1.142 g/cm³
• LogP: 1.47280
• Storage Temp.: -20?C Freezer
• Water Solubility.: 4.21g/L at 20℃
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 4
• Exact Mass: 180.078644241
• Heavy Atom Count: 13
• Complexity: 160

Purity/Quality:

99% ^*data from raw suppliers

2-[(2-Methoxyphenoxy)methyl]oxirane ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=CC=C1OCC2CO2

Technology Process of 1-(2-Methoxyphenoxy)-2,3-epoxypropane

There total 22 articles about 1-(2-Methoxyphenoxy)-2,3-epoxypropane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

sodium 2-methoxyphenolate (13052-77-2) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 2-(2-methoxy-phenoxymethyl)-oxirane (2210-74-4)

Guidance literature:

at 20 ℃; for 24h;

DOI:10.1111/cbdd.12285

Reference yield: 94.0%

2-methoxy-phenol (90-05-1) + epichlorohydrin (106-89-8,24969-06-0,13403-37-7) → 2-(2-methoxy-phenoxymethyl)-oxirane (2210-74-4)

Guidance literature:

2-methoxy-phenol; With sodium hydroxide; In water; at 30 ℃; Large scale;

epichlorohydrin; In water; at 25 - 35 ℃; Large scale;

DOI:10.1021/op300056k

Reference yield: 90.0%

(S)-epichlorohydrin (67843-74-7,24969-06-0,13403-37-7) + sodium 2-methoxyphenolate (13052-77-2) → (R)-1,2-epoxy-3-(2-methoxyphenyloxy)-propane (2210-74-4,61248-98-4,61248-99-5,95721-91-8)

Guidance literature:

at 20 ℃; for 24h;

DOI:10.1111/cbdd.12285

upstream raw materials:

peracetic acid

O-allyl guaiacol

1,3-Dichloro-2-propanol

2-methoxy-phenol

Downstream raw materials:

(R)-3-methyl-8-<3-(2-methoxyphenoxy)-2-hydroxypropyl>-1-oxa-3,8-diazaspiro<4.5>decan-2-one

(S)-1,2-epoxy-3-(2-methoxyphenyloxy)-propane

(R)-1,2-epoxy-3-(2-methoxyphenyloxy)-propane

(S)-guaifenesin

Refernces

• 1、 Shindikar,Viswanathan. "Efficient synthesis of 8-methoxy-3,4-dihydro-2H-1-benzopyran-3-ol". . p. 1141 - 1145. Retrieved 2011.
• 2、 Gokel, George W.,Dishong, Dennis M.,Diamond, Craig J.. "Lariat Ethers. Synthesis and Cation Binding of Macrocyclic Polyethers Possessing Axially Disposed Secondary Donor Groups". . p. 1053 - 1054. Retrieved 1980.
• 3、 Jia, Shilong,Jin, Cheng-Yun,Li, Xiaobo,Liu, Mengbo,Meng, Xia,Wang, Menglin,Wu, Xinxin,Xu, Hai-Wei,Yu, Lu. "A low toxic CRM1 degrader: Synthesis and anti-proliferation on MGC803 and HGC27". . . Retrieved 2020/08/19.
• 4、 O'Reilly, Molly,Kirkwood, Nerissa K.,Kenyon, Emma J.,Huckvale, Rosemary,Cantillon, Daire M.,Waddell, Simon J.,Ward, Simon E.,Richardson, Guy P.,Kros, Corné J.,Derudas, Marco. "Design, Synthesis, and Biological Evaluation of a New Series of Carvedilol Derivatives That Protect Sensory Hair Cells from Aminoglycoside-Induced Damage by Blocking the Mechanoelectrical Transducer Channel". . p. 5312 - 5329. Retrieved 2019/06/07.