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CAS No.: | 2210-74-4 |
---|---|
Name: | Guaiacol glycidyl ether |
Article Data: | 49 |
Molecular Structure: | |
Formula: | C10H12O3 |
Molecular Weight: | 180.203 |
Synonyms: | Benzene,1-(2,3-epoxypropoxy)-2-methoxy- (6CI,7CI,8CI);Oxirane,[(2-methoxyphenoxy)methyl]- (9CI);1,2-Epoxy-3-(2-methoxyphenoxy)propane;1,2-Epoxy-3-(o-methoxyphenoxy)propane;1-(2-Methoxyphenoxy)-2,3-epoxypropane;2-(2,3-Epoxypropoxy)anisole;2-Methoxy-1-(oxiranylmethoxy)benzene;2-Methoxyphenyl glycidyl ether;2-[(2-Methoxyphenoxy)methyl]oxirane;Glycidyl2-methoxyphenyl ether;NSC 112256;NSC 133442; |
EINECS: | 218-644-8 |
Density: | 1.142 g/cm3 |
Melting Point: | 33-36 °C |
Boiling Point: | 265.3 °C at 760 mmHg |
Flash Point: | 87.4 °C |
Solubility: | 4.21g/L at 20℃ |
Appearance: | White crystalline solid |
PSA: | 30.99000 |
LogP: | 1.47280 |
sodium 2-methoxyphenolate
epichlorohydrin
2-(2-methoxy-phenoxymethyl)-oxirane
Conditions | Yield |
---|---|
at 20℃; for 24h; | 95% |
Conditions | Yield |
---|---|
Stage #1: 2-methoxy-phenol With sodium hydroxide In water at 30℃; Large scale; Stage #2: epichlorohydrin In water at 25 - 35℃; Large scale; | 94% |
With potassium carbonate at 120℃; for 4.5h; | 93% |
With n-Bu4NOSO2OCH2CHOHCH3; potassium carbonate at 75 - 80℃; for 1h; | 90% |
2-methoxy-phenol
1,2-Epoxy-3-bromopropane
2-(2-methoxy-phenoxymethyl)-oxirane
Conditions | Yield |
---|---|
With potassium carbonate In tetrahydrofuran Heating; | 82% |
With potassium carbonate In N,N-dimethyl-formamide at 70℃; for 6h; | 62% |
With base | |
With potassium carbonate In butanone at 80℃; |
2-methoxy-phenol
epichlorohydrin
A
1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol
B
2-(2-methoxy-phenoxymethyl)-oxirane
Conditions | Yield |
---|---|
With sodium hydroxide In water for 7h; Heating; | A 23% B 68% |
With sodium hydroxide In 1,4-dioxane; water at 25 - 30℃; | |
With sodium hydroxide at 25 - 30℃; |
Conditions | Yield |
---|---|
With diethyl ether |
Conditions | Yield |
---|---|
With sodium hydroxide | |
With sodium hydroxide |
Conditions | Yield |
---|---|
tris-(3,6-dioxa-octyl)amine In acetonitrile |
2-methoxy-phenol
epichlorohydrin
A
1,3-bis(2-methoxyphenoxy)propan-2-ol
B
2-(2-methoxy-phenoxymethyl)-oxirane
Conditions | Yield |
---|---|
Stage #1: 2-methoxy-phenol With sodium hydroxide; tetrabutylammomium bromide In water; toluene at 25 - 30℃; for 0.5h; Stage #2: epichlorohydrin In water; toluene at 35 - 40℃; for 6h; Product distribution / selectivity; | |
With sodium hydroxide at 10 - 15℃; Temperature; |
2-methoxy-phenol
epichlorohydrin
A
1-chloro-3-(2-methoxyphenoxy)-2-propyl alcohol
B
1,3-bis(2-methoxyphenoxy)propan-2-ol
C
guaifenesin
D
2-(2-methoxy-phenoxymethyl)-oxirane
Conditions | Yield |
---|---|
With sodium hydroxide In toluene at 25 - 30℃; Solvent; Concentration; |
Conditions | Yield |
---|---|
at 20℃; | 99% |
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IUPAC Name: 2-[(2-Methoxyphenoxy)methyl]oxirane
Following is the structure of Oxirane,2-[(2-methoxyphenoxy)methyl]- (CAS NO.2210-74-4):
Empirical Formula: C10H12O3
Molecular Weight: 180.2005
EINECS: 218-644-8
Index of Refraction: 1.526
Molar Refractivity: 48.45 cm3
Molar Volume: 157.7 cm3
Density: 1.142 g/cm3
Flash Point: 87.4 °C
Melting point: 33-36 °C
Polarizability: 19.2 10-24cm3
Surface Tension: 40.4 dyne/cm
Enthalpy of Vaporization: 48.29 kJ/mol
Boiling Point: 265.3 °C at 760 mmHg
Vapour Pressure: 0.0152 mmHg at 25 °C
Appearance of Oxirane,2-[(2-methoxyphenoxy)methyl]- (CAS NO.2210-74-4): White Crystalline Solid
Product Categories: INTERMEDIATESOFRANOLAZINE; API intermediates; Various Intermediates; Intermediates; Intermediates & Fine Chemicals; Pharmaceuticals; Ranolazine
Canonical SMILES: COC1=CC=CC=C1OCC2CO2
InChI: InChI=1S/C10H12O3/c1-11-9-4-2-3-5-10(9)13-7-8-6-12-8/h2-5,8H,6-7H2,1H3
InChIKey: RJNVSQLNEALZLC-UHFFFAOYSA-N
Oxirane,2-[(2-methoxyphenoxy)methyl]- (CAS NO.2210-74-4) can be used as Ranolazine intermediate.
Organism | Test Type | Route | Reported Dose (Normalized Dose) | Effect | Source |
---|---|---|---|---|---|
mouse | LD50 | subcutaneous | 1355mg/kg (1355mg/kg) | BEHAVIORAL: MUSCLE CONTRACTION OR SPASTICITY) | Arzneimittel-Forschung. Drug Research. Vol. 15, Pg. 1355, 1965. |
Oxirane,2-[(2-methoxyphenoxy)methyl]- , its cas register number 2210-74-4. It also can be called 1,2-Epoxy-3-(o-methoxyphenoxy)propane ; Guajacol-glycidaether ; Guajacol-glycidaether [German] ; NSC 112256 ; NSC 133442 ; and Propane, 1,2-epoxy-3-(o-methoxyphenoxy)- .