Technology Process of (1S,2R,5S)-2-isopropyl-5-methylcyclohexyl cinnamate
There total 4 articles about (1S,2R,5S)-2-isopropyl-5-methylcyclohexyl cinnamate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
tetrakis(acetonitrile)palladium bistriflate; (S)-4-methyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole; sodium carbonate; silver carbonate;
In
1,2-dichloro-ethane;
at 130 ℃;
for 12h;
Sealed tube;
Inert atmosphere;
DOI:10.1021/acs.orglett.1c00296
- Guidance literature:
-
With
C21H35BrMnN2O2P; potassium tert-butylate;
In
1,4-dioxane;
at 120 ℃;
for 30h;
Overall yield = 71.6 percent; Overall yield = 102 mg;
Inert atmosphere;
DOI:10.1002/adsc.202001209
- Guidance literature:
-
Multi-step reaction with 2 steps
1: ethanol / 20 °C
2: silver carbonate; sodium carbonate; tetrakis(acetonitrile)palladium bistriflate; (S)-4-methyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole / 1,2-dichloro-ethane / 12 h / 130 °C / Sealed tube; Inert atmosphere
With
tetrakis(acetonitrile)palladium bistriflate; (S)-4-methyl-2-(5-(trifluoromethyl)pyridin-2-yl)-4,5-dihydrooxazole; sodium carbonate; silver carbonate;
In
ethanol; 1,2-dichloro-ethane;
2: |Heck Reaction;
DOI:10.1021/acs.orglett.1c00296
