108945-28-4

Upstream product

• 2216-51-5 (-)-menthol 
• 79-10-7 acrylic acid 
• 89-78-1 menthol 
• 814-68-6 acryloyl chloride 
• 15356-70-4 menthol 
• 86198-29-0 cyclohexanone oxime acrylate 
• 15356-60-2 (1S,2R,5S)-(+)-menthol 
• 292638-85-8 acrylic acid methyl ester 

Downstream Products

• 1315276-27-7 C₂₇H₃₂N₂O₃ 
• 1315276-12-0 C₂₁H₂₇NO₄ 
• 132455-34-6 (2S,4S,5R)-2-Methyl-5-phenyl-pyrrolidine-2,4-dicarboxylic acid 4-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester 
• 132455-44-8 (2R,4S,5R)-2,5-Diphenyl-pyrrolidine-2,4-dicarboxylic acid 4-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester 
• 132455-33-5 (2S,4S,5R)-5-Naphthalen-2-yl-pyrrolidine-2,4-dicarboxylic acid 4-((1S,2R,5S)-2-isopropyl-5-methyl-cyclohexyl) ester 2-methyl ester 
• 161201-92-9 1S,2R,5S-menthyl-r-2S-methoxycarbonyl-2-methyl-c-5S-(2'-iodophenyl)pyrrolidine-c-4R-carboxylate 
• 161201-94-1 1S,2R,5S-menthyl r-2S-methoxycarbonyl-2-phenyl-c-5S-(2'-iodophenyl)pyrrolidine-c-4R-carboxylate 
• 161201-93-0 1S,2R,5S-menthyl 2S-benzyl-r-2-methoxycarbonyl-c-5S-(2'-iodophenyl)pyrrolidine-c-4R-carboxylate 
• 161201-95-2 1S,2R,5S-menthyl r-2S-methoxycarbonyl-2-methyl-c-5S-(4'-iodo-N-phenylsuphonylindol-3'-yl)pyrrolidine-c-4R-carboxylate 
• 161201-97-4 1S,2R,5S-menthyl r-2S-methoxycarbonyl-2-phenyl-c-5S-(4'-iodo-N-phenylsuphonylindol-3'-yl)pyrrolidine-c-4R-carboxylate 
• 161201-96-3 1S,2R,5S-menthyl 2S-benzyl-r-2-methoxycarbonyl-c-5S-(4'-iodo-N-phenylsuphonylindol-3'-yl)pyrrolidine-c-4R-carboxylate 
• 145146-26-5 (R)-3,3,3-Trifluoro-2-methoxy-2-phenyl-propionic acid (S)-2,2-bis-methylsulfanyl-cyclobutylmethyl ester 

Relevant academic research and scientific papers

Menthols as Chiral Auxiliaries for Asymmetric Cycloadditive Oligomerization: Syntheses and Studies of β-Proline Hexamers

To produce a novel class of structurally ordered poly-β-prolines, an emergent method for synthesizing chiral β-peptide molecular frameworks was developed based on 1,3-dipolar cycloaddition chemistry of azomethine ylides. Functionalized short β-peptides wi

Chiral activated alkenes induced asymmetric Baylis-Hillman reaction in Me3N/H2O/solvent medium

Chiral-activated alkenes, L-menthyl acrylate and (+)-N-α-phenylethyl acrylamide, induced asymmetric Baylis-Hillman reaction of aromatic aldehydes was realized at 25°C for 7 days in Me3N/H2O/solvent homogeneous medium. The correspondi

A Method For Preparing (Meth)Acrylic Acid Ester Based Compound

The invention relates to a method for preparing a (meth)acrylic acid ester-based compound, and according to the preparation method, a (meth)acrylic acid ester-based compound can be prepared with high purity and high yield, by easily introducing an acrylic structure into alcohol using a diamine-based compound and acid anhydride.

Ru(II)-Catalyzed Oxidative Olefination of Benzamides: Switchable Aza-Michael and Aza-Wacker Reaction for Synthesis of Isoindolinones

Selective tandem oxidative C-H olefination-aza-Michael/aza-Wacker reaction of N-arylbenzamides is achieved by fine-tuning between base and additive to access valuable 3-oxoisoindolinyls and 3-oxoisoindolinylidenes, respectively. Careful optimization and c

Four Stereoisomers of 2-Aminomethyl-1-cyclopropanecarboxylic Acid: Synthesis and biological evaluation

Here, we report a practical method for asymmetric synthesis of cyclopropane-fused GABA analogs. Starting from 2-furaldehyde, the cis-isomer (CAMP) was synthesized over 10 steps; (1)- and (+)-CAMP￠HCl were synthesized by employing d- and l-menth

Photoredox-Coupled F-Nucleophilic Addition: Allylation of gem-Difluoroalkenes

A novel strategy for the expedient construction of CF3-embeded tertiary/quarternary carbon centers was developed by taking advantage of photoredox catalysis. Thanks to a key step of single-electron oxidation, electron-rich gem-difluoroalkenes, which otherwise are essentially reluctant towards F-nucleoplilic addition, now readily participate in this fluoroallylation reaction. Furthermore, this strategy provides an elegant example for the generation, as well as functionalization, of α-CF3-substituted benzylic radical intermediates using cheap and readily available starting materials.

Photoredox/Cobalt Dual Catalysis for Visible-Light-Mediated Alkene-Alkyne Coupling

Dual photoredox transition-metal catalysis has recently emerged as a powerful tool for making synthetically challenging carbon-carbon bonds under milder reaction conditions. Herein, we report on the visible-light-mediated controlled generation of low-valent cobalt catalyst without the need for a metallic reductant. It enabled C-C bond formation via ene-yne coupling at room temperature. The generality of this dual catalysis is demonstrated via the creation of sizable molecular diversity with the accommodation of several functional groups.

Intermolecular Carboamination of Unactivated Alkenes

Herein, we report the first example of group transfer radical addition of O-vinylhydroxylamine derivatives onto unactivated alkenes. By utilizing O-vinylhydroxylamine derivatives as both the N- and C-donors, this reaction enables intermolecular carboamination of unactivated alkenes in an atom economical fashion. As the process is initiated through N-radical addition followed by C-transfer, linear carboamination products are afforded. This differs from canonical radical carbofunctionalization of olefins, which typically favors branched product owing to initiation by C-radical addition.

METHOD OF FABRICATING ACRYLIC MONOMER COMPRISING ALIPHATIC CYCLIC COMPOUND DERIVED NATURAL AND ACRYLIC MONOMER FABRICATED THEREBY AND ACRYLIC PRESSURE-SENSITIVE ADHESIVE COMPOSITION INCLUDING THE SAME

Provided are a synthesis method of an acrylic monomer comprising a naturally derived aliphatic cyclic compound, an acrylic monomer synthesized thereby, and an acrylic pressure-sensitive adhesive composition comprising the same. More particularly, the synthesis method comprises the steps of: preparing a naturally derived aliphatic cyclic compound including a hydroxyl functional group at the end; and having a reaction between the aliphatic cyclic compound and an acrylic acid derivative and synthesizing an acrylic monomer comprising a naturally derived aliphatic cyclic compound. Therefore, the acrylic pressure-sensitive adhesive composition has enhanced adhesive strength when bonded to an object by the acrylic monomer synthesized with a naturally derived aliphatic cyclic compound, and can easily separate a panel from an LCD by being capable of easily detached therefrom. Further, the acrylic pressure-sensitive adhesive composition can have minimized environmental burden by being synthesized with a naturally derived aliphatic cyclic compound.(S10) Step of preparing a naturally derived aliphatic cyclic compound including a hydroxyl functional group at the end(S20) Step of having a reaction between the aliphatic cyclic compound and an acrylic acid derivative and synthesizing an acrylic monomer comprising a naturally derived aliphatic cyclic compoundCOPYRIGHT KIPO 2016

METALLOPROTEASE INHIBITORS, METHODS FOR PRODUCING SAME, AND THERAPEUTIC USES THEREOF

The invention relates to new α-vinyl carbonylated compounds corresponding to general formula (I), wherein R1, R2, R3, R4, R5 and Y are as defined in claim 1, their isomers, their diastereoisomers and