rel-(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole

Base Information

Chemical Name:rel-(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole
CAS No.:548472-49-7
Molecular Formula:C₂₅H₂₄Cl₂N₂O₂
Molecular Weight:455.384
Hs Code.:

Synonyms:548472-49-7;rel-(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole;1ttv;1H-Imidazole,4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-methoxy-2-(1-methylethoxy)phenyl]-,(4R,5S)-;1H-IMidazole,4,5-bis(4-chlorophenyl)-4,5-dihydro-2-[4-Methoxy-2-(1-Methylethoxy)phenyl]-,(4R,5S)-rel-

Suppliers and Price of rel-(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 6 raw suppliers

Chemical Property of rel-(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole

Chemical Property:

Boiling Point:576.0±60.0 °C(Predicted)
PKA:8.13±0.70(Predicted)
Density:1.26±0.1 g/cm3(Predicted)
XLogP3:6.1
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:6
Exact Mass:454.1214834
Heavy Atom Count:31
Complexity:600

Purity/Quality:: ≥95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:CC(C)OC1=C(C=CC(=C1)OC)C2=NC(C(N2)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl
Isomeric SMILES:CC(C)OC1=C(C=CC(=C1)OC)C2=N[C@@H]([C@@H](N2)C3=CC=C(C=C3)Cl)C4=CC=C(C=C4)Cl

Technology Process of rel-(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole

There total 5 articles about rel-(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 86212-34-2,91044-20-1,98674-96-5,74641-30-8
(1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine

: 107811-48-3
2-isopropoxy-4-methoxybenzene-1-carboaldehyde

: 548472-49-7
(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: (1R,2S)-1,2-bis(4-chlorophenyl)ethane-1,2-diamine; 2-isopropoxy-4-methoxybenzene-1-carboaldehyde; In dichloromethane; at 0 ℃; for 2h;

With N-Bromosuccinimide; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/j.bmcl.2008.07.114

Reference yield:

: 115294-32-1
C₂₈H₂₀Cl₄N₂O

: 548472-49-7
(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: sulfuric acid / 1 h / Reflux

2.1: dichloromethane / 0.5 h / Cooling with ice

2.2: 20 °C / Inert atmosphere

With sulfuric acid; In dichloromethane;

Reference yield:

: 95-01-2
2,4-Dihydroxybenzaldehyde

: 548472-49-7
(4R,5S)-4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-4,5-dihydro-1H-imidazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium carbonate / acetone / 5 h / Reflux

2.1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 40 °C / Inert atmosphere

3.1: dichloromethane / 0.5 h / Cooling with ice

3.2: 20 °C / Inert atmosphere

With potassium carbonate; In dichloromethane; N,N-dimethyl-formamide; acetone;