107811-48-3

Basic information

• Product Name: Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)-
• Synonyms: Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)-;4-Methoxy-2-(propan-2-yloxy)benzaldehyde
• CAS NO: 107811-48-3
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.22706
• Mol File: 107811-48-3.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 317.4°Cat760mmHg
• Flash Point: 136.7°C
• Appearance: /
• Density: 1.064g/cm³
• Vapor Pressure: 0.000386mmHg at 25°C
• Refractive Index: 1.521
• CAS DataBase Reference: Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)-(107811-48-3)
• EPA Substance Registry System: Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)-(107811-48-3)

Safety Data

• Hazardous Substances Data: 107811-48-3(Hazardous Substances Data)

Usage

Description

Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)-, also known as Vanillin Methyl Ether, is a chemical compound with the molecular formula C10H14O2. It is a colorless liquid characterized by a distinctive almond-like odor. This versatile compound is widely used across various industries due to its unique properties and applications.

Uses

Used in the Food Industry:
Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)is used as a flavoring agent for its almond-like aroma, enhancing the taste and smell of various food products.
Used in the Perfume Industry:
It serves as a fragrance ingredient in perfumes, contributing to the creation of complex and long-lasting scents.
Used as a Precursor in Pharmaceutical Production:
Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)is utilized as a starting material in the synthesis of various pharmaceuticals, playing a crucial role in the development of new medications.
Used in Organic Compound Synthesis:
It acts as a precursor in the production of other organic compounds, facilitating the creation of a wide range of chemical products.
Used in Industrial and Agricultural Applications:
Due to its potential antimicrobial and insecticidal properties, Benzaldehyde, 4-Methoxy-2-(1-Methylethoxy)is employed in various industrial processes and agricultural settings to control microbial growth and pests, respectively.

InChI:InChI=1/C11H14O3/c1-8(2)14-11-6-10(13-3)5-4-9(11)7-12/h4-8H,1-3H3

Upstream product

• 95-01-2 2,4-Dihydroxybenzaldehyde 
• 673-22-3 2-Hydroxy-4-methoxybenzaldehyde 
• 75-30-9 2-iodo-propane 
• 75-26-3 isopropyl bromide 

Downstream Products

• 1229390-29-7 3-(2-i-propoxy-4-methoxybenzylidene)anabaseine 
• 1630041-29-0 C₂₅H₂₄N₂O₂ 
• 1630041-30-3 4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-1H-imidazole 
• 1630041-31-4 C₂₇H₂₂F₆N₂O₂ 
• 1630041-48-3 N,N-diethyl-2-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)-ethanamine 
• 1630041-47-2 4-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)morpholine 
• 1630041-46-1 1-(3-(2-(2-isopropoxy-4-methoxyphenyl)-4,5-bis(4-(trifluoromethyl)phenyl)-imidazol-1-yl)propyl)piperidine 
• 1630041-45-0 4-(3-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-1H-imidazol-1-yl)propyl)morpholine 
• 1630041-44-9 4-(2-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-1H-imidazol-1-yl)ethyl)morpholine 
• 1630041-43-8 1-(3-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-imidazol-1-yl)propyl)-4-methylpiperazine 
• 1630041-42-7 1-(2-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-1H-imidazol-1-yl)ethyl)-4-methylpiperazine 
• 1630041-41-6 3-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-1H-imidazol-1-yl)-N,N-diethylpropan-1-amine 
• 1630041-40-5 2-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-1H-imidazol-1-yl)-N,N-diethylethanamine 
• 1630041-39-2 1-(3-(4,5-bis(4-chlorophenyl)-2-(2-isopropoxy-4-methoxyphenyl)-imidazol-1-yl)propyl)piperidine 

Relevant articles and documents

Dimer ester micromolecule PROTACs for inducing MDM2 to self-degrade E3 ubiquitin ligase

The invention provides dimer ester micromolecule PROTACs for inducing MDM2 to self-degrade E3 ubiquitin ligase. The structure of the PROTACs is shown in the specification, wherein in a compound (I), L1 is C1-C30 linear or branched alkyl with or without a substituent group, and any carbon atom in L1 is optionally replaced by heteroatom; R1, R2, R3 and R4 are C1-C30 linear or branched alkyl with orwithout a substituent group, C1-C30 aryl with or a without substituent group, C1-C30 linear or branched alkylaryl with or without a substituent group or C1-C30 linear or branched aryl alkyl with or without a substituent group respectively and independently; X1, X2, X3 and X4 are halogen respectively and independently.

Design, synthesis and biological evaluation of 2, 4, 5-triphenylimidazole derivatives with preliminary SAR

A series of N1-substituted 2,4,5-triphenyl imidazole derivatives was designed, synthesized and evaluated for their p53-MDM2 binding inhibitory activities and anti-proliferative activities in vitro against four human cancer cell lines (PC3, KB, A549 and HCT116). Although logical evaluation revealed weak p53-MDM2 binding inhibitory activities, most of the obtained molecules displayed moderate to potent cytotoxicities against tested cell lines. As a potential lead compound for further optimization, compound 9c was evaluated as the most potent compound against four cell lines and could induce cell cycle arrest at G2/M phase. The binding mode of compound 9f and MDM2 was further studied by docking analysis and the unexpected interaction mode revealed that this series of compounds may take part into a different binding modes as the lead compound Such as Nutlin, which could induce a different mechanism in cancer therapy.

Design, synthesis and CoMFA studies of N1-amino acid substituted 2,4,5-triphenyl imidazoline derivatives as p53-MDM2 binding inhibitors

A series of novel N1-amino-acid substituted 2,4,5-triphenyl imidazoline derivatives was designed and synthesized based on our previous studies. All synthesized target compounds were screened for their p53-MDM2 binding inhibitory activities and anti-proliferative activities against five cancer cell lines. Among them, twelve compounds displayed improved binding inhibitory activities and most compounds showed higher cell growth inhibition activities with IC 50 values in the low micromolar range. Compound 6c exhibited marked p53-MDM2 binding inhibitory activity (IC50 = 0.59 μM) which was eightfold more potent than that of Nutlin-1 (IC50 = 4.78 μM). CoMFA analysis was performed based on obtained biological data and resulted in a statistically significant CoMFA model with high predict abilities (q 2 = 0.645, r2 = 0.979).