methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

Base Information

Chemical Name:methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate
CAS No.:1065272-06-1
Molecular Formula:CH₄O₃S*C₂₆H₂₈F₆N₂O₅
Molecular Weight:658.616
Hs Code.:

Synonyms:methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

Suppliers and Price of methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

Chemical Property:

Purity/Quality:: 98% HPLC ^*data from raw suppliers

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Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

There total 1 articles about methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 75-75-2,98527-29-8
methanesulfonic acid

: methyl 3-[(6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate

: 1065272-06-1
methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

Guidance literature:: In toluene; at 0 - 25 ℃;

Reference yield:

: 1065272-06-1
methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

: 552292-08-7
Rolapitant

Guidance literature:: methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate; With acetic acid; zinc; at 25 - 60 ℃;

With hydrogenchloride; In water; toluene;

With sodium carbonate; In water; toluene;

Reference yield:

: 1065272-06-1
methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate

: 858102-79-1
Rolapitant hydrochloride

Guidance literature:: methyl 3-[(3S,6S)-6-({(1R)-1-[3,5-bis(trifluoromethyl)phenyl]ethoxy}methyl)-3-nitro-6-phenylpiperidin-3-yl]propanoate methylsulfonate; With acetic acid; zinc; at 20 - 60 ℃;

With hydrogenchloride; In ethanol; water; isopropyl alcohol; toluene; at 0 - 25 ℃;