Technology Process of 3-(3,4-dimethoxyphenyl)-7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline
There total 15 articles about 3-(3,4-dimethoxyphenyl)-7,8-dimethoxy-2-tosyl-1,2,3,4-tetrahydroisoquinoline which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
N,N-dimethyl-formamide;
at 0 - 20 ℃;
for 3h;
DOI:10.1021/ol300180w
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: boron trichloride / hexane; dichloromethane / 2 h / -10 °C
2.1: N-Bromosuccinimide; C32H19N2O8P / dichloromethane / 1 h / 0 °C
3.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C
4.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C
4.2: -78 - 0 °C
5.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; hexane / 1 h / 20 °C
6.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C
With
N-Bromosuccinimide; C32H19N2O8P; n-butyllithium; dihydrogen peroxide; boron trichloride; sodium hydride; sodium hydroxide;
In
tetrahydrofuran; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ol300180w
- Guidance literature:
-
Multi-step reaction with 11 steps
1.1: copper(l) iodide; tetrakis(triphenylphosphine) palladium(0); tetra-(n-butyl)ammonium iodide; triethylamine / acetonitrile / 48 h / 20 °C / Reflux
2.1: palladium 10% on activated carbon; hydrogen / methanol; ethyl acetate / 3 h / 20 °C / 760.05 Torr
3.1: lithium aluminium tetrahydride / diethyl ether / 2 h / 0 - 20 °C / Inert atmosphere
4.1: manganese(IV) oxide / toluene / 12 h / 20 °C / Reflux
5.1: scandium tris(trifluoromethanesulfonate) / 1,2-dichloro-ethane / 24 h / 20 °C / Reflux
6.1: boron trichloride / hexane; dichloromethane / 2 h / -10 °C
7.1: N-Bromosuccinimide; C32H21O4P / dichloromethane / 1 h / 0 °C
8.1: sodium hydride / N,N-dimethyl-formamide / 1.5 h / 0 - 20 °C
9.1: n-butyllithium / tetrahydrofuran; hexane / 0.08 h / -78 °C
9.2: -78 - 0 °C
10.1: dihydrogen peroxide; sodium hydroxide / tetrahydrofuran; hexane / 1 h / 20 °C
11.1: sodium hydride / N,N-dimethyl-formamide / 3 h / 0 - 20 °C
With
manganese(IV) oxide; N-Bromosuccinimide; copper(l) iodide; lithium aluminium tetrahydride; tetrakis(triphenylphosphine) palladium(0); C32H21O4P; n-butyllithium; palladium 10% on activated carbon; hydrogen; dihydrogen peroxide; boron trichloride; tetra-(n-butyl)ammonium iodide; sodium hydride; triethylamine; sodium hydroxide; scandium tris(trifluoromethanesulfonate);
In
tetrahydrofuran; methanol; diethyl ether; hexane; dichloromethane; ethyl acetate; 1,2-dichloro-ethane; N,N-dimethyl-formamide; toluene; acetonitrile;
DOI:10.1021/ol300180w
