3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

Base Information

Chemical Name:3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid
CAS No.:1377936-23-6
Molecular Formula:C₂₉H₃₁N₃O₃
Molecular Weight:469.583
Hs Code.:

Synonyms:3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

Suppliers and Price of 3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

There total 7 articles about 3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1377936-42-9
1-(3,4-dimethylbenzyl)-N-(4-formylphenyl)-5-methyl-1H-indole-3-carboxamide

: 107-95-9
3-amino propanoic acid

: 1377936-23-6
3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

Guidance literature:: With sodium cyanoborohydride; acetic acid; In methanol; at 20 ℃; for 2h;

Reference yield:

: 1377936-27-0
1-(3,4-dimethylbenzyl)-5-methyl-1H-indole-3-carboxylic acid

: 1377936-23-6
3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

Guidance literature:: Multi-step reaction with 4 steps

1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

2: triethylamine / dichloromethane / 20 °C

3: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / acetonitrile / 2 h / 20 °C

4: sodium cyanoborohydride; acetic acid / methanol / 2 h / 20 °C

With oxalyl dichloride; sodium cyanoborohydride; acetic acid; 4-methylmorpholine N-oxide; triethylamine; tetrapropylammonium perruthennate; N,N-dimethyl-formamide; In methanol; dichloromethane; acetonitrile;

Reference yield:

: 227960-12-5
methyl 5-methyl-1H-indole-3-carboxylate

: 1377936-23-6
3-(4-{[1-(3,4-Dimethyl-benzyl)-5-methyl-1H-indole-3-carbonyl]-amino}-benzylamino)-propionic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: caesium carbonate / acetonitrile / 3 h / 50 °C / Reflux

2.1: sodium hydroxide; water / tetrahydrofuran; methanol / 16 h / 80 °C

2.2: 0 °C

3.1: oxalyl dichloride / N,N-dimethyl-formamide / dichloromethane / 20 °C

4.1: triethylamine / dichloromethane / 20 °C

5.1: 4-methylmorpholine N-oxide / tetrapropylammonium perruthennate / acetonitrile / 2 h / 20 °C

6.1: sodium cyanoborohydride; acetic acid / methanol / 2 h / 20 °C

With oxalyl dichloride; water; sodium cyanoborohydride; caesium carbonate; acetic acid; 4-methylmorpholine N-oxide; triethylamine; sodium hydroxide; tetrapropylammonium perruthennate; N,N-dimethyl-formamide; In tetrahydrofuran; methanol; dichloromethane; acetonitrile;