1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

Base Information

Chemical Name:1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate
CAS No.:157701-51-4
Molecular Formula:C₂₂H₂₆N₂O₇S
Molecular Weight:462.524
Hs Code.:

Synonyms:1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

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Chemical Property of 1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

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Technology Process of 1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

There total 2 articles about 1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3144-09-0
methanesulfonamide

: 24325-17-5
N-benzyloxycarbonyl-α-benzylester-δ-L-α-aminoadipic acid

: 157701-51-4
1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

Guidance literature:: With dmap; dicyclohexyl-carbodiimide; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1021/jm9803727

Reference yield:

: 157701-51-4
1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

Guidance literature:

Reference yield:

: 157701-51-4
1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

: (S)-2-{4-[(2,7-Dimethyl-4-oxo-3,4-dihydro-quinazolin-6-ylmethyl)-prop-2-ynyl-amino]-2-fluoro-benzoylamino}-6-methanesulfonylamino-6-oxo-hexanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: H₂ / 10 percent Pd/C / acetic acid / 2 h / 20 °C

2: HOBT; Et₃N / dimethylformamide; dimethylsulfoxide / 0.75 h / 20 °C

3: 82 percent / ammonia in MeOH / 16 h / 20 °C

With ammonia; hydrogen; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Hydrogenation / 2: Condensation / 3: Hydrolysis;
DOI:10.1021/jm9803727