(S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

Base Information

Chemical Name:(S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid
CAS No.:247904-25-2
Molecular Formula:C₃₄H₄₀FN₅O₉S
Molecular Weight:713.784
Hs Code.:

(S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

Synonyms:(S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

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Chemical Property of (S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

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Technology Process of (S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

There total 3 articles about (S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 24325-17-5
N-benzyloxycarbonyl-α-benzylester-δ-L-α-aminoadipic acid

: 247904-25-2
(S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

Guidance literature:: Multi-step reaction with 3 steps

1: dicyclohexylcarbodiimide; 4-(dimethylamino)pyridine / CH₂Cl₂ / 24 h / 20 °C

2: H₂ / 10 percent Pd/C / acetic acid / 2 h / 20 °C

3: HOBT; Et₃N / dimethylformamide; dimethylsulfoxide / 0.75 h / 20 °C

With dmap; hydrogen; benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In dichloromethane; acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Condensation / 2: Hydrogenation / 3: Condensation;
DOI:10.1021/jm9803727

Reference yield:

: 157701-51-4
1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate

: 247904-25-2
(S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

Guidance literature:: Multi-step reaction with 2 steps

1: H₂ / 10 percent Pd/C / acetic acid / 2 h / 20 °C

2: HOBT; Et₃N / dimethylformamide; dimethylsulfoxide / 0.75 h / 20 °C

With hydrogen; benzotriazol-1-ol; triethylamine; palladium on activated charcoal; In acetic acid; dimethyl sulfoxide; N,N-dimethyl-formamide; 1: Hydrogenation / 2: Condensation;
DOI:10.1021/jm9803727

Reference yield:

: 153538-13-7
pentafluorophenyl 4--6-quinazolinyl>methyl>-N-prop-2-ynylamino>-2-fluorobenzoate

: 157701-50-3
(2S)-2-amino-5-[(N-methylsulphonyl)carbamoyl]pentanoic acid

: 247904-25-2
(S)-2-[[4-[N-[[3,4-dihydro-2,7-dimethyl-4-oxo-3-[(pivaloyloxy)methyl]-6-quinazolinyl]methyl]-N-prop-2-ynylamino]-2-fluorobenzoyl]amino]-5-[N-(methanesulfonyl)amino]carboxypentanoic acid

Guidance literature:: With benzotriazol-1-ol; triethylamine; In dimethyl sulfoxide; N,N-dimethyl-formamide; at 20 ℃; for 0.75h;
DOI:10.1021/jm9803727