24325-17-5

Upstream product

• 24325-14-2 (2S)-2-[(phenylmethoxy)carbonyl]aminoadipic acid 
• 908094-04-2 phenyldiazomethane 
• 65926-39-8 (R)-benzyl 2-(((benzyloxy)carbonyl)amino)-3-iodopropanoate 
• 79-10-7 acrylic acid 
• 24325-12-0 (+/-)-2-chloroacetaminohexanedioic acid 
• 100-44-7 benzyl chloride 
• 84246-50-4 (S)-2-Benzyloxycarbonylamino-6-formyloxy-hexanoic acid benzyl ester 
• 84246-49-1 2(S)-2-(benzyloxycarbonylamino)-6-hydroxyhexanoic acid, benzyl ester 
• 1118-90-7 L-homoglutamic acid 
• 100-39-0 benzyl bromide 
• 501-53-1 benzyl chloroformate 
• 102922-72-5 (S)-2-(((benzyloxy)carbonyl)amino)-6-hydroxyhexanoic acid 
• 657-27-2 L-Lysine hydrochloride 
• 14511-39-8 2(S)-2-amino-6-(benzylideneamino)hexanoic acid 

Downstream Products

• 133406-42-5 N-benzyloxycarbonyl-α-benzylester-δ-L-α-aminoadipoyl-O-benzyl-D-serine 
• 157701-51-4 1-benzyl (2S,)-2-benzyloxycarbonylamino-5-[(N-methylsulphonyl)carbamoyl]-pentanoate 
• 84246-49-1 2(S)-2-(benzyloxycarbonylamino)-6-hydroxyhexanoic acid, benzyl ester 
• 81306-86-7 δ-(α-benzyl, N^α-carbobenzoxy-L-α-aminoadipyl)-O-benzyl-L-seryl-D-valine benzyl ester 
• 87829-66-1 6-[((S)-5-Benzyloxycarbonyl-5-benzyloxycarbonylamino-pentanoylamino)-methyl]-2-(4-nitro-phenyl)-[1,3]oxazinane-3-carboxylic acid benzyl ester 
• 79761-06-1 (N-benzyloxycarbonyl)-α-benzylester-δ-(L-α-aminoadipoyl)-S-benzyl-L-<3-13C>cysteinyl-D-valine benzylester 
• 79761-05-0 N-benzyloxycarbonyl-α-benzyl-δ-(L-α-aminoadipoyl)-S-benzyl-L-cysteinyl-D-valine benzyl ester 
• 81306-86-7 N-benzyloxycarbonyl-α-benzylester-δ-L-α-aminoadipoyl-O-benzyl-D-serinyl-D-valine benzylester 
• 69644-78-6 bis[Aad(-Cys-D-Val)] 
• 103548-47-6 (S)-benzyl 2-benzyloxycarbonylamino-9-(4-imidazolyl)-7-azanonanoate 
• 79761-07-2 N-benzyloxycarbonyl-α-benzyl-δ-(L-α-aminoadipoyl)-S-benzyl-L-<3-13C>cysteinyl-D-<3-13C>valine benzyl ester 
• 79761-15-2 N-benzyloxycarbonyl-α-benzyl-δ-(L-α-aminoadipoyl)-S-benzyl-L-<3-13C>cysteine 
• 79761-10-7 [(N-benzyloxycarbonyl)-(α-benzyl)-δ-(L-α-aminoadipoyl)]-S-benzyl-L-cysteine 
• 87829-75-2 (R)-6-[((S)-5-Benzyloxycarbonyl-5-benzyloxycarbonylamino-pentylamino)-methyl]-2-(4-nitro-phenyl)-[1,3]oxazinane-3-carboxylic acid benzyl ester 

Relevant academic research and scientific papers

Applications of Radical Addition Reactions to the Synthesis of a C-Glucoside and a Functionalised Amino-acid

Addition of carbon radicals derived from tetra-acetylglucosyl and β-alanyl derivatives to acrylic acid or esters provides a short route to a C-glucoside and a functionalised α-amino-acid, respectively.

Tricyclic compounds with pharmaceutical activity

The invention relates to tricyclic compounds of formula (I) STR1 wherein R1 is hydrogen, amino, (1-4C)alkyl, (1-4C)alkoxy, hydroxy-(1-4C)alkyl or fluoro-(1-4C)alkyl; R2 is hydrogen, (1-4C)alkyl, (3-4C)alkenyl, (3-4C)alkynyl, hydroxy-(2-4C)alkyl, halogeno-(2-4C)alkyl or cyano-(1-4C)alkyl; Ar is optionally-substituted phenylene, thiophenediyl, thiazolediyl, pyridinediyl or pyrimidinediyl; and R3 includes a group of the formula --NHCH(CO2 H)--A1 --Y1 wherein A1 is (1-6C)alkylene and Y1 is carboxy, tetrazol-5-yl, N-?(1-4C)alkylsulphonyl!carbamoyl, N(phenylsulphonyl)carbamoyl, tetrazol-5-ylthio, tetrazol-5-ylsulphinyl or tetrazol-5-ylsulphonyl; or pharmaceutically-acceptable salts or esters thereof; to processes for their manufacture; to pharmaceutical compositions containing them; and to their use as anti-cancer agents.

SYNTHESIS OF N-BENZYLOXYCARBONYL-L-α-AMINOADIPIC ACID, α-BENZYL ESTER

A new synthesis of N-benzyloxycarbonyl-L-α-aminoadipic acid, α-benzyl ester (1) from L-lysine monohydrochloride (2) is reported.

AN EFFICIENT SYNTHESIS OF δ-(L-α-AMINOADIPYL)-L-SERYL-D-VALINE (LLD ASV), A NATURALLY OCCURING TRIPEPTIDE FROM THE FERMENTATION OF Penicillium chrysogenum

The synthesis of δ-(L-α-aminoadipyl)-L-seryl-D-valine (LLD ASV), a naturally occuring congener of the well known tripeptide δ-(L-α-aminoadipyl)-L-cysteinyl-D-valine (LLD ACV) which is the linear precursor of isopenicillin N, penicillin N cephalosporin C i

SYNTHESIS OF THE RACEMIC AND OPTICALLY ACTIVE FORMS OF GIZZEROSINE, THE INDUCER OF GIZZARD EROSION IN CHICKS

The racemate end both the (R)- and (S)-forms of gizzerosine were synthesised, and the (S)-isomer was identified as the toxic substance in fish meal causing severe gizzard erosion (black vomit) in chicks.

Direct Preparation of α>-Diprotected L-α-Aminoadipic Acid from L-Lysine

L-Lysine was converted into N-benzyloxycarbonyl-L-α-aminoadipic acid 1-benzyl ester by a short route which avoids the intermediacy of L-α-aminoadipic acid.

Conversion of 17O/18O-Labelled &δ-(L-&α-Aminoadipyl)-L-cysteinyl-D-valine into 17O/18O-Labelled Isopenicillin N in a Cell-free Extract of C. acremonium

δ-(L-α-Amino17O/18O>-adipyl)-L-cysteinyl-D-valine was converted into isopenicillin N in cell-free extracts of Cephalosporium acremonium with no loss of 17O/18O label as shown by 17O n.m.r. spectroscopy and mass spectrometry; incubation of unlabelled tripeptide in a cell-free system containing 17O/18O-enriched water produced isopenicillin N with no incorporation of 17O/18O.

Synthesis of δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine and some Carbon-13 and Nitrogen-15 Labelled Isotopomers

δ-(L-α-Aminoadipoyl)-L-cysteinyl-D-valine (7a), δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (7b), δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (7c), and δ-(L-α-aminoadipoyl)-L-cysteinyl-D-valine (7d) were prepared by conv