Technology Process of 3-chloro-4-(6-hydroxyquinolin-2-yl)benzamide
There total 6 articles about 3-chloro-4-(6-hydroxyquinolin-2-yl)benzamide which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
3-chloro-4-(6-hydroxyquinolin-2-yl)benzoic acid;
With
thionyl chloride;
for 1h;
Reflux;
With
ammonium hydroxide;
at 30 ℃;
for 1h;
With
hydrogenchloride;
In
water;
pH=6;
- Guidance literature:
-
Multi-step reaction with 6 steps
1.1: dihydrogen peroxide / water; acetic acid / 21 h / 70 °C
1.2: pH 8 - 9
2.1: acetic anhydride / 2 h / Reflux
3.1: trichlorophosphate / 2 h / Reflux
4.1: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere
5.1: aluminum (III) chloride / dichloromethane / Reflux
6.1: thionyl chloride / 1 h / Reflux
6.2: 1 h / 30 °C
6.3: pH 6
With
aluminum (III) chloride; thionyl chloride; 2-(2-methoxyethoxy)ethyl alcohol; dihydrogen peroxide; acetic anhydride; potassium carbonate; trichlorophosphate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
dichloromethane; water; acetic acid;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: potassium carbonate; 2-(2-methoxyethoxy)ethyl alcohol / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / water / 3 h / 110 °C / Inert atmosphere
2.1: aluminum (III) chloride / dichloromethane / Reflux
3.1: thionyl chloride / 1 h / Reflux
3.2: 1 h / 30 °C
3.3: pH 6
With
aluminum (III) chloride; thionyl chloride; 2-(2-methoxyethoxy)ethyl alcohol; potassium carbonate;
(1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride;
In
dichloromethane; water;
