Technology Process of 3-((3R,3aR,7R,7aS)-octahydro-1,5-dioxo-3-phenyl-1H-isoindol-7-yl)propyl formate
There total 5 articles about 3-((3R,3aR,7R,7aS)-octahydro-1,5-dioxo-3-phenyl-1H-isoindol-7-yl)propyl formate which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: 100 percent / triethylamine / CH2Cl2 / 18 h / 0 °C
2.1: NaH / dimethylformamide / 12 h
2.2: 75 percent / dimethylformamide / 24 h
3.1: 34 percent / (R)-N-isopropyl-1-phenylethylamine lithium salt / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
4.1: tert-butyl lithium / diethyl ether; hexane / -78 - 20 °C
4.2: Li[Cu(CN)Me] / diethyl ether; hexane / 20 °C
4.3: 79 percent / diethyl ether; hexane / 2 h / -78 °C
5.1: 90 percent / 0.5 h / Heating
With
lithium R-(-)-N-isopropyl-1-phenylethyl amide; tert.-butyl lithium; sodium hydride; triethylamine;
In
tetrahydrofuran; diethyl ether; hexane; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja042415g
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: NaH / dimethylformamide / 12 h
1.2: 75 percent / dimethylformamide / 24 h
2.1: 34 percent / (R)-N-isopropyl-1-phenylethylamine lithium salt / tetrahydrofuran; hexane / 5 h / -78 - 20 °C
3.1: tert-butyl lithium / diethyl ether; hexane / -78 - 20 °C
3.2: Li[Cu(CN)Me] / diethyl ether; hexane / 20 °C
3.3: 79 percent / diethyl ether; hexane / 2 h / -78 °C
4.1: 90 percent / 0.5 h / Heating
With
lithium R-(-)-N-isopropyl-1-phenylethyl amide; tert.-butyl lithium; sodium hydride;
In
tetrahydrofuran; diethyl ether; hexane; N,N-dimethyl-formamide;
DOI:10.1021/ja042415g
