(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

Base Information

Chemical Name:(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide
CAS No.:810675-86-6
Molecular Formula:C₃₄H₃₇NO₂Si
Molecular Weight:519.759
Hs Code.:

Synonyms:(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

Suppliers and Price of (Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

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Technology Process of (Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

There total 1 articles about (Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: (1R,2S)-2-(tert-Butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropanecarbaldehyde

: 29601-98-7
N-benzylhydroxylamine hydrochloride

: 810675-86-6
(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

Guidance literature:: In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/jo048637e

Reference yield: 50.0%

: 810675-86-6
(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

: 75-16-1
methylmagnesium bromide

: 810675-87-7
N-benzyl-N-{1-[2-(tert-butyl-diphenyl-silanyloxymethyl)-2-phenyl-cyclopropyl]-ethyl}-hydroxylamine

Guidance literature:: With magnesium bromide; In tetrahydrofuran; diethyl ether; toluene; at -78 ℃; for 8h;
DOI:10.1021/jo048637e

Reference yield:

: 810675-86-6
(Z)-N-[(1R,2S)-2-tert-butyldiphenylsilyloxymethyl-2-phenylcyclopropylmethylene]benzylamine N-oxide

: (1S,4S,5R)-4-methyl-2-oxo-1-phenyl-3-benzyl-3-azabicyclo[3.1.0]hexane

Guidance literature:: Multi-step reaction with 4 steps

1: 50 percent / MgBr₂ / diethyl ether; tetrahydrofuran; toluene / 8 h / -78 °C

2: 77 percent / Zn; AcOH / CH₂Cl₂ / 3 h / 20 °C

3: 100 percent / TBAF / tetrahydrofuran / 12 h / 20 °C

4: 94 percent / PDC / CH₂Cl₂ / 12 h / 20 °C

With dipyridinium dichromate; tetrabutyl ammonium fluoride; acetic acid; magnesium bromide; zinc; In tetrahydrofuran; diethyl ether; dichloromethane; toluene; 1: Grignard addition;
DOI:10.1021/jo048637e