[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Base Information

Chemical Name:[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol
CAS No.:135068-35-8
Molecular Formula:C₃₄H₄₃NO₅S
Molecular Weight:577.785
Hs Code.:

Synonyms:[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

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Chemical Property of [(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

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Technology Process of [(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

There total 10 articles about [(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

: 135068-30-3
(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridine-2-carboxylic acid butyl ester

: 135068-35-8
[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Guidance literature:: With lithium aluminium tetrahydride; In diethyl ether;
DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

: 19803-37-3
Tetrakis(benzyloxy)titanium

: 135068-35-8
[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 8 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

With lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74295-X

Reference yield:

: 89461-51-8
[(2S,3S)-3-pentyloxiran-2-yl]methanol

: 135068-35-8
[(2R,6S)-6-((1S,2R)-1,2-Bis-benzyloxy-heptyl)-1-(toluene-4-sulfonyl)-1,2,3,6-tetrahydro-pyridin-2-yl]-methanol

Guidance literature:: Multi-step reaction with 8 steps

2: (COCl)2, N(C₂H₅)3 / dimethylsulfoxide; CH₂Cl₂

3: NaH / diethyl ether

4: 90 percent / DIBAH / CH₂Cl₂

5: PDC / dimethylformamide

6: tetrahydrofuran

7: 81 percent / 144 h / 40 °C

8: 92 percent / LAH / diethyl ether

With lithium aluminium tetrahydride; dipyridinium dichromate; oxalyl dichloride; sodium hydride; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane; dimethyl sulfoxide; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)74295-X