2-Bromo-3-fluorophenol

Base Information

• Chemical Name: 2-Bromo-3-fluorophenol
• CAS No.: 443-81-2
• Molecular Formula: C6H4BrFO
• Molecular Weight: 191
• Hs Code.: 2908190090
• Mol file: 443-81-2.mol

Synonyms:3-Fluoro-5-bromophenol;

Chemical Property of 2-Bromo-3-fluorophenol

Chemical Property:

• Appearance/Colour: light yellow liquid
• Vapor Pressure: 0.288mmHg at 25°C
• Refractive Index: 1.576
• Boiling Point: 196.141 °C at 760 mmHg
• PKA: 7.43±0.10(Predicted)
• Flash Point: 72.424 °C
• PSA: 20.23000
• Density: 1.764 g/cm³
• LogP: 2.29380
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

99% ^*data from raw suppliers

2-Bromo-3-fluorophenol ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T, Xn
• Hazard Codes: T,Xn
• Statements: 20/21/22-36/37/38-22
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Uses: 2-Bromo-3-fluorophenol has been used as a reactant in the preparation of diaryl ethers.

Technology Process of 2-Bromo-3-fluorophenol

There total 7 articles about 2-Bromo-3-fluorophenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

3-fluorophenol (372-20-3) → 2-bromo-3-fluorophenol (443-81-2)

Guidance literature:

With 1-butyl-3-methylpyridinium tribromide; at 20 ℃; for 0.166667h;

DOI:10.1016/j.tetlet.2008.12.053

Reference yield: 91.0%

1-bromo-2,6-difluorobenzene (64248-56-2) → 2-bromo-3-fluorophenol (443-81-2)

Guidance literature:

1-bromo-2,6-difluorobenzene; With potassium trimethylsilonate; In diethylene glycol dimethyl ether; at 120 ℃; for 5h; Inert atmosphere;

With hydrogenchloride; In diethylene glycol dimethyl ether; water; at 20 ℃; Inert atmosphere;

DOI:10.1055/s-0028-1087564

Reference yield: 75.0%

O-2-bromo-3-fluorophenyl N,N-diethylcarbamate (863870-75-1) → 2-bromo-3-fluorophenol (443-81-2)

Guidance literature:

With sodium hydroxide; In ethanol; Heating;

DOI:10.1021/jo0508402

upstream raw materials:

3-fluorophenol

sulfuric acid

O-2-bromo-3-fluorophenyl N,N-diethylcarbamate

3-fluorophenyl N,N-diethyl-O-carbamate

Downstream raw materials:

3-bromo-2-fluoro-4-hydroxy-benzaldehyde

3-bromo-4-fluoro-2-hydroxy-benzaldehyde

2-(2-bromo-3-fluorophenoxy)-acetaldehyde diethyl acetal

4-bromo-1-benzofuran

Refernces

• 1、 Borikar, Sanjay P.,Daniel, Thomas,Paul, Vincent. "An efficient, rapid, and regioselective bromination of anilines and phenols with 1-butyl-3-methylpyridinium tribromide as a new reagent/solvent under mild conditions". scheme or table. p. 1007 - 1009. Retrieved 2009/05/11.
• 2、 Sanz, Roberto,Castroviejo, M. Pilar,Fernandez, Yolanda,Fananas, Francisco J.. "A new and efficient synthesis of 4-functionalized benzo[6]furans from 2,3-dihalophenols". . p. 6548 - 6551. Retrieved 2007/10/03.