1-methyl-2-phenylpyrrolidine

Base Information

• Chemical Name: 1-methyl-2-phenylpyrrolidine
• CAS No.: 938-36-3
• Molecular Formula: C11H15 N
• Molecular Weight: 161.247
• Mol file: 938-36-3.mol

Synonyms:1-Methyl-2-phenylpyrrolidine;NSC 66254

Chemical Property of 1-methyl-2-phenylpyrrolidine

Chemical Property:

• Vapor Pressure: 0.0854mmHg at 25°C
• Boiling Point: 225.6°C at 760 mmHg
• Flash Point: 82.1°C
• Density: 0.983g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 1-methyl-2-phenylpyrrolidine

There total 51 articles about 1-methyl-2-phenylpyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

(RS) 1-methyl-2-phenylpyrrolidine-2-carbaldehyde (180407-33-4) → 1-methyl-2-phenylpyrrolidine (938-36-3)

Guidance literature:

With sodium hydroxide; at 50 ℃; for 16h;

Reference yield: 91.0%

(S)-(-)-1-methyl-5-phenylpyrrolidin-2-one → (S)-(-)-1-methyl-2-phenylpyrrolidine (938-36-3,2512-64-3,58166-84-0,58166-86-2)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 70 ℃; for 24h;

DOI:10.1021/jo400127x

Reference yield: 90.0%

1-methyl-5-phenyl-2,3-dihydro-pyrrole (4170-67-6) → (S)-(-)-1-methyl-2-phenylpyrrolidine (938-36-3,2512-64-3,58166-84-0,58166-86-2)

Guidance literature:

With bis(1,5-cyclooctadiene)diiridium(I) dichloride; C₃₃H₃₂NO₂P; hydrogen; iodine; In tetrahydrofuran; at 20 ℃; for 3h; under 760.051 Torr; optical yield given as %ee; enantioselective reaction;

DOI:10.1021/ja808358r

upstream raw materials:

1-methyl-pyrrolidin-2-one

2-(phenyl)pyrrolidine

methyl iodide

1-methyl-5-phenyl-2,3-dihydro-pyrrole

Downstream raw materials:

1,1-dimethyl-2-phenylpyrrolidinium iodide

1-Acetoxy-4-(acetymethylamino)-1-phenylbutan

1-methyl-3-phenyl-piperidin-2-one

1,1-dimethyl-2-phenyl-pyrrolidinium