N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide

Base Information

• Chemical Name: N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide
• CAS No.: 113628-52-7
• Molecular Formula: C₁₇H₁₂ClN₅O
• Molecular Weight: 337.768

Synonyms:N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide

Chemical Property of N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide

Chemical Property:

Purity/Quality:

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Technology Process of N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide

There total 2 articles about N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

N-{4-[(4-Chloro-phthalazin-1-yl)-hydrazonomethyl]-phenyl}-acetamide (87539-61-5) → N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide (113628-52-7)

Guidance literature:

With bromine; sodium acetate; In acetic acid; for 1h; Ambient temperature;

DOI:10.1021/jm00401a010

Reference yield:

para-acetamidobenzaldehyde (122-85-0) → N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide (113628-52-7)

Guidance literature:

Multi-step reaction with 2 steps

2: bromine

With bromine;

Reference yield: 87.0%

pyrrolidine (123-75-1) + N-[4-(6-Chloro-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide (113628-52-7) → 3-(4-acetylaminophenyl)-6-(1-pyrrolidinyl)-1,2,4-triazolo[3,4-a]phthalazine (87540-06-5)

Guidance literature:

at 140 ℃; for 30h;

DOI:10.1021/jm00401a010

upstream raw materials:

N-{4-[(4-Chloro-phthalazin-1-yl)-hydrazonomethyl]-phenyl}-acetamide

para-acetamidobenzaldehyde

Downstream raw materials:

3-(4-acetylaminophenyl)-6-(1-pyrrolidinyl)-1,2,4-triazolo[3,4-a]phthalazine

N-[4-(6-Ethoxy-[1,2,4]triazolo[3,4-a]phthalazin-3-yl)-phenyl]-acetamide

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