ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate

Base Information

Chemical Name:ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate
CAS No.:137517-94-3
Molecular Formula:C₁₉H₂₃NO₃
Molecular Weight:313.397
Hs Code.:

Synonyms:ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate

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Chemical Property of ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate

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Technology Process of ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate

There total 3 articles about ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 5130-24-5
Vinyl chloroformate

: trans-decahydro-4a-(3-methoxyphenyl)-2-methyl-6-methyleneisoquinoline

: 137517-94-3
ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate

Guidance literature:: With potassium carbonate; In 1,2-dichloro-ethane; for 1.5h; Heating;
DOI:10.1021/jm00079a005

Reference yield:

: 73224-22-3
1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

: 137517-94-3
ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) n-BuLi, 3.) NaI, K₂CO₃

2: 83 percent / 1.) MeSO₃H, 2.) NaBH₄ / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min

3: 95 percent / K₂CO₃ / 1,2-dichloro-ethane / 1.5 h / Heating

With sodium tetrahydroborate; n-butyllithium; methanesulfonic acid; potassium carbonate; sodium iodide; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00079a005

Reference yield:

: 137517-45-4
2,3,4,4a,5,6,7,8-octahydro-4a-(3-methoxyphenyl)-2-methyl-6-methyleneisoquinoline

: 137517-94-3
ethenyl (+/-)-trans-3,4,4a,5,8,8a-hexahydro-4a-(3-methoxyphenyl)-2(1H)-isoquinolinecarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 83 percent / 1.) MeSO₃H, 2.) NaBH₄ / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min

2: 95 percent / K₂CO₃ / 1,2-dichloro-ethane / 1.5 h / Heating

With sodium tetrahydroborate; methanesulfonic acid; potassium carbonate; In methanol; 1,2-dichloro-ethane;
DOI:10.1021/jm00079a005