(4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol

Base Information

Chemical Name:(4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol
CAS No.:137517-79-4
Molecular Formula:C₂₆H₃₃NO₂Se
Molecular Weight:470.514
Hs Code.:

Synonyms:(4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol

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Chemical Property of (4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol

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Technology Process of (4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol

There total 6 articles about (4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

: 71098-88-9
N-phenylselanylphthalimide

: 137517-76-1
trans-2-(cyclopropylmethyl)-1,2,3,4,4a,5,8,8a-octahydro-4a-(3-methoxyphenyl)isoquinoline

: 137517-79-4
(4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol

Guidance literature:: With toluene-4-sulfonic acid; In acetonitrile; for 24h; Ambient temperature;
DOI:10.1021/jm00079a005

Reference yield:

: 73224-22-3
1-methyl-4-(3-methoxyphenyl)-1,2,3,6-tetrahydropyridine

: 137517-79-4
(4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol

Guidance literature:: Multi-step reaction with 6 steps

1: 1.) n-BuLi, 3.) NaI, K₂CO₃

2: 83 percent / 1.) MeSO₃H, 2.) NaBH₄ / methanol / 1.) from -60 to 25 deg C, 5 min, 2.) RT, 30 min

3: 95 percent / K₂CO₃ / 1,2-dichloro-ethane / 1.5 h / Heating

4: 91 percent / HCl / methanol / 6 h / Heating

5: NaHCO₃ / dimethylformamide / 4 h / 150 °C

6: 93 percent / aq. pTSA / acetonitrile / 24 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; n-butyllithium; methanesulfonic acid; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; sodium iodide; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00079a005

Reference yield:

: trans-decahydro-4a-(3-methoxyphenyl)-2-methyl-6-methyleneisoquinoline

: 137517-79-4
(4aα,6α,7β,8aβ)-2-(cyclopropylmethyl)decahydro-4a-(3-methoxyphenyl)-6-(phenylselenyl)-7-isoquinolinol

Guidance literature:: Multi-step reaction with 4 steps

1: 95 percent / K₂CO₃ / 1,2-dichloro-ethane / 1.5 h / Heating

2: 91 percent / HCl / methanol / 6 h / Heating

3: NaHCO₃ / dimethylformamide / 4 h / 150 °C

4: 93 percent / aq. pTSA / acetonitrile / 24 h / Ambient temperature

With hydrogenchloride; sodium hydrogencarbonate; potassium carbonate; toluene-4-sulfonic acid; In methanol; 1,2-dichloro-ethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1021/jm00079a005