(3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone

Base Information

Chemical Name:(3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone
CAS No.:116180-71-3
Molecular Formula:C₂₀H₂₀Cl₂O₄S
Molecular Weight:427.348
Hs Code.:

Synonyms:(3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone

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Technology Process of (3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone

There total 6 articles about (3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 116180-70-2
(S)-(E)-1-(3,4-Dimethoxyphenyl)prop-1-enyl p-toluene sulfoxide

: 76-02-8
trifluoroacetyl chloride

: 116180-71-3
(3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone

Guidance literature:: With copper; zinc; In tetrahydrofuran; at 0 ℃; for 0.166667h;
DOI:10.1055/s-1987-28177

Reference yield: 60.0%

: 104329-38-6
1,2-Dimethoxy-4-[(E)-1-(toluene-4-sulfinyl)-propenyl]-benzene

: 76-02-8
trifluoroacetyl chloride

: 104310-49-8,116180-71-3
(4S,5R)-3,3-Dichloro-5-(3,4-dimethoxy-phenyl)-4-methyl-5-p-tolylsulfanyl-dihydro-furan-2-one

Guidance literature:: With copper; zinc; In diethyl ether; Heating;
DOI:10.1016/S0040-4039(00)98213-3

Reference yield:

: 1517-82-4
(1R,2S,5R,SS)-(-)-menthyl p-toluenesulfinate

: 116180-71-3
(3R,4S)-2,2-Dichloro-4-(3,4-dimethoxyphenyl)-3-methyl-4-p-tolylthiobutyrolactone

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) s-BuLi / 1.) Et₂O, cyclohexane, -78 deg C, 1 h, 2.) ether, -78 deg C to room temp., 6 h

2: 76 percent / Zn-Cu / tetrahydrofuran / 0.17 h / 0 °C

With sec.-butyllithium; copper; zinc; In tetrahydrofuran;
DOI:10.1055/s-1987-28177