7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Base Information

• Chemical Name: 7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide
• CAS No.: 452307-99-2
• Molecular Formula: C₁₄H₁₃FN₂O₂S
• Molecular Weight: 292.334

Synonyms:7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Chemical Property of 7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

Chemical Property:

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Technology Process of 7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

There total 4 articles about 7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

benzaldehyde (100-52-7) + 2-amino-5-fluoro-3-methyl-benzenesulfonamide (452307-90-3) → 7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide (452307-99-2)

Guidance literature:

With (1S)-10-camphorsulfonic acid; In acetonitrile; for 24h;

DOI:10.1016/S0968-0896(01)00405-9

Reference yield:

4-fluor-2-methylaniline (452-71-1) → 7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide (452307-99-2)

Guidance literature:

Multi-step reaction with 4 steps

1: various solvent(s) / -42 °C

2: aluminium trichloride / various solvent(s) / 2 h / -42 - 110 °C

3: sulfuric acid / water / 2 h / 130 - 140 °C

4: (1S)-10-camphorsulfonic acid / acetonitrile / 24 h

With aluminium trichloride; sulfuric acid; (1S)-10-camphorsulfonic acid; In water; acetonitrile;

DOI:10.1016/S0968-0896(01)00405-9

Reference yield:

C8H8ClFN2O3S → 7-fluoro-5-methyl-3-phenyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide (452307-99-2)

Guidance literature:

Multi-step reaction with 3 steps

1: aluminium trichloride / various solvent(s) / 2 h / -42 - 110 °C

2: sulfuric acid / water / 2 h / 130 - 140 °C

3: (1S)-10-camphorsulfonic acid / acetonitrile / 24 h

With aluminium trichloride; sulfuric acid; (1S)-10-camphorsulfonic acid; In water; acetonitrile;

DOI:10.1016/S0968-0896(01)00405-9

upstream raw materials:

benzaldehyde

2-amino-5-fluoro-3-methyl-benzenesulfonamide

4-fluor-2-methylaniline

Downstream raw materials:

(4-benzyl-7-fluoro-3,5-dimethyl-1,1-dioxo-3,4-dihydro-1H-1λ⁶-benzo[1,2,4]thiadiazin-2-yl)-acetic acid methyl ester

4-benzyl-7-fluoro-3,5-dimethyl-3,4-dihydro-2H-benzo[1,2,4]thiadiazine 1,1-dioxide

2-benzylamino-5-fluoro-3-methyl-benzenesulfonamide

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