Chemical Property of 2'-Deoxy-2'-fluorouridine
Chemical Property:
- Melting Point:147.0 to 153.0 °C
- Refractive Index:53 ° (C=0.3, H2O)
- PKA:9.39±0.10(Predicted)
- PSA：104.55000
- Density:1.63 g/cm3
- LogP:-1.87470
- Storage Temp.:under inert gas (nitrogen or Argon) at 2-8°C
- Solubility.:Soluble in methanol.
- XLogP3:-1
- Hydrogen Bond Donor Count:3
- Hydrogen Bond Acceptor Count:6
- Rotatable Bond Count:2
- Exact Mass:246.06519962
- Heavy Atom Count:17
- Complexity:374
- Purity/Quality:
-
97% *data from raw suppliers
2''-Fluoro-2''-deoxyuridine *data from reagent suppliers
Safty Information:
- Pictogram(s):
Xn
- Hazard Codes:Xn
- Statements:
20/21/22-40
- Safety Statements:
22-36/37/39
- MSDS Files:
-
SDS file from LookChem
Useful:
- Canonical SMILES:C1=CN(C(=O)NC1=O)C2C(C(C(O2)CO)O)F
- Isomeric SMILES:C1=CN(C(=O)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)F
-
Description
2'-Deoxy-2'-fluorouridine is a nucleoside analog that inhibits the replication of wild-type viruses by binding to the viral RNA. 2'-Deoxy-2'-fluorouridine has been shown to inhibit the replication of resistant mutants in vitro, and this inhibition can be reversed by increasing the concentration of 2'-deoxy-2'-fluorouridine. 2'-Deoxy-2'-fluorouridine also binds to duplexes of dsDNA with high affinity and specificity.
-
Uses
2'-Fluoro-2'-deoxyuridine is used as a component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer. A component incorporated into therapeutic oligonucleotides to combat prostate and breast cancer.
