Technology Process of C7H4ClIO2
There total 3 articles about C7H4ClIO2 which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
formaldehyd;
With
triethylamine; magnesium chloride;
In
tetrahydrofuran;
at 20 ℃;
for 0.166667h;
3-chloro-2-iodo-phenol;
In
tetrahydrofuran;
for 3h;
Heating / reflux;
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 2 h / -78 °C
1.2: 2.5 h / -78 - 20 °C
2.1: sodium hydroxide / ethanol / 14 h / Heating / reflux
3.1: triethylamine; magnesium chloride / tetrahydrofuran / 0.17 h / 20 °C
3.2: 3 h / Heating / reflux
With
sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; triethylamine; magnesium chloride;
In
tetrahydrofuran; ethanol; cyclohexane;
- Guidance literature:
-
Multi-step reaction with 4 steps
1.1: sodium hydride / tetrahydrofuran / 1.17 h
1.2: 14 h / 20 °C
2.1: N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium / tetrahydrofuran; cyclohexane / 2 h / -78 °C
2.2: 2.5 h / -78 - 20 °C
3.1: sodium hydroxide / ethanol / 14 h / Heating / reflux
4.1: triethylamine; magnesium chloride / tetrahydrofuran / 0.17 h / 20 °C
4.2: 3 h / Heating / reflux
With
sodium hydroxide; N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; sodium hydride; triethylamine; magnesium chloride;
In
tetrahydrofuran; ethanol; cyclohexane;