5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Base Information

• Chemical Name: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
• CAS No.: 124750-51-2
• Molecular Formula: C33H25BrN4
• Molecular Weight: 557.492
• European Community (EC) Number: 603-010-9
• DSSTox Substance ID: DTXSID80434768
• Nikkaji Number: J1.204.303A
• Wikidata: Q72446891
• Mol file: 124750-51-2.mol

Synonyms:5-[4'-(Bromomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole;N-Triphenylmethyl-5-[4'-(bromomethyl)biphenyl-2-yl]tetrazole;[2'-(N-Trityltetrazol-5-yl)biphenyl-4-yl]methyl bromide;1-Triphenylmethyl-5-[4'-(bromomethyl)biphenyl-2-yl]tetrazole;4'-Bromomethyl-2-(1-triphenylmethyltetrazol-5-yl)biphenyl;5-(4'-Bromomethylbiphenyl-2-yl)-1-trityl-1H-tetrazole;

Chemical Property of 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

Chemical Property:

• Appearance/Colour: off-white solid
• Melting Point: 152-155 °C
• Boiling Point: 718.441 °C at 760 mmHg
• PKA: 0.29±0.10(Predicted)
• Flash Point: 388.299 °C
• PSA: 43.60000
• Density: 1.282 g/cm³
• LogP: 7.74220
• Storage Temp.: -20?C Freezer
• XLogP3: 8.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 7
• Exact Mass: 556.12626
• Heavy Atom Count: 38
• Complexity: 660

Purity/Quality:

99% ^*data from raw suppliers

5-(4'-(BROMOMETHYL)(1,1'-BIPHENYL)-2-YL)-1-TRITYL-1H-TETRAAZOLE Aldrich ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C(C2=CC=CC=C2)(C3=CC=CC=C3)N4C(=NN=N4)C5=CC=CC=C5C6=CC=C(C=C6)CBr
• Uses: An intermediate in the synthesis of Losartan and Valsartan

Technology Process of 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole

There total 35 articles about 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.2%

N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole (124750-53-4) → N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2)

Guidance literature:

With bromine; In hexane; water; at 69 ℃; for 0.433333h; Temperature; Solvent; Irradiation; Flow reactor;

Reference yield: 95.07%

4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl (154709-18-9) → N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2)

Guidance literature:

With phosphorus tribromide; In dichloromethane; at 10 - 20 ℃; for 1h;

Reference yield: 7.0%

N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole (124750-53-4) → N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole (124750-51-2) + 5-(4'-Dibromomethyl-biphenyl-2-yl)-1-trityl-1H-tetrazole

Guidance literature:

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic acid; In dichloromethane; for 16h; Heating;

DOI:10.1021/jm00033a006

upstream raw materials:

N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole

salicylonitrile

4-tolyl iodide

o-cyanobromobenzene

Downstream raw materials:

1-[2'-(1-triphenylmethyl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-benzotriazole

(1, 1-dimethyl-2-(4-oxo-5-(2'-(N-triphenylmethyltetrazol-5-yl)biphenyl-4-ylmethyl)-2,3,4,5-tetrahydro-1H-naphtho[2,1-b]azepin-3-ylcarbamoyl)ethyl)-carbamic acid tert-butyl ester

2-Ethyl-7-methoxy-4-[(2'-(1H-tetrazol-5-yl)biphenyl-4-yl)methoxy]quinoline hydrochloride

5-{2-Butyl-1-[2'-(1-trityl-1H-tetrazol-5-yl)-biphenyl-4-ylmethyl]-1H-imidazol-4-yl}-pyrimidine 1-oxide

Refernces

• 1、 -. "Method for tubular reaction preparation of substituted benzylically brominated methyl biphenyl and reaction device of method". Paragraph 0022-0029. . Retrieved 2018/06/15.
• 2、 -. "1,(3,)5-substituted imidazoles, useful in the treatment of hypertension and methods for their preparation". Paragraph 0219. . Retrieved 2016/03/04.