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CAS No.: | 124750-51-2 |
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Name: | 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole |
Article Data: | 29 |
Molecular Structure: | |
Formula: | C33H25BrN4 |
Molecular Weight: | 557.492 |
Synonyms: | 5-[4'-(Bromomethyl)[1,1'-biphenyl]-2-yl]-1-(triphenylmethyl)-1H-tetrazole;N-Triphenylmethyl-5-[4'-(bromomethyl)biphenyl-2-yl]tetrazole;[2'-(N-Trityltetrazol-5-yl)biphenyl-4-yl]methyl bromide;1-Triphenylmethyl-5-[4'-(bromomethyl)biphenyl-2-yl]tetrazole;4'-Bromomethyl-2-(1-triphenylmethyltetrazol-5-yl)biphenyl;5-(4'-Bromomethylbiphenyl-2-yl)-1-trityl-1H-tetrazole; |
EINECS: | 603-010-9 |
Density: | 1.282 g/cm3 |
Melting Point: | 152-155 °C |
Boiling Point: | 718.441 °C at 760 mmHg |
Flash Point: | 388.299 °C |
Appearance: | off-white solid |
PSA: | 43.60000 |
LogP: | 7.74220 |
N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
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With bromine In hexane; water at 69℃; for 0.433333h; Temperature; Solvent; Irradiation; Flow reactor; | 95.2% |
With sodium bromate; sodium hydrogensulfite In water; 1,2-dichloro-ethane at 20℃; Product distribution / selectivity; | 90% |
With N-Bromosuccinimide; dihydrogen peroxide In dichloromethane Reflux; | 88% |
4'-hydroxymethyl-2-(N-trityl-1H-tetrazol-5-yl)biphenyl
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With phosphorus tribromide In dichloromethane at 10 - 20℃; for 1h; | 95.07% |
With sulfuric acid; potassium bromide In N,N-dimethyl acetamide at 10 - 25℃; for 7h; Reagent/catalyst; Solvent; | 81.4% |
N-triphenylmethyl-5-(4'-methylbiphenyl-2-yl)tetrazole
A
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); sodium acetate; acetic acid In dichloromethane for 16h; Heating; | A 76% B 7% |
With 1,3-dibromo-5,5-dimethylimidazolidine-2,4-dione; 2,2'-azobis(isobutyronitrile) In chlorobenzene at 80℃; Overall yield = 78.6 %; |
salicylonitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
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Multi-step reaction with 4 steps 1: 98 percent / pyridine / 1.) 0 deg C, 5 min, 2.) r.t., 25 h 2: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 3: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 4: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
4-tolyl iodide
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 3: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
o-cyanobromobenzene
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 3: NBS, AIBN / CCl4 / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: bis-triphenylphosphine-palladium(II) chloride; lithium chloride / N,N-dimethyl-formamide / Inert atmosphere 2: sodium azide; tributyltin chloride / toluene / Reflux 3: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane View Scheme | |
Multi-step reaction with 4 steps 1.1: palladium dichloride / methanol; toluene / 0.17 h / 20 °C / Inert atmosphere 1.2: 12 h / 110 °C / Inert atmosphere 2.1: zinc(II) chloride; sodium azide / N,N-dimethyl-formamide / 48 h / 120 °C 3.1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux 4.1: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux View Scheme |
2-Cyano-4'-methylbiphenyl
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 2: NBS, AIBN / CCl4 / 3 h / Heating View Scheme | |
Multi-step reaction with 3 steps 1: sodium azide; triethylamine hydrochloride / toluene / 18 h / 105 - 110 °C 2: toluene / 3 h / 20 °C 3: N-Bromosuccinimide; dihydrogen peroxide / dichloromethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: sodium azide; tributyltin chloride / toluene / Reflux 2: N-Bromosuccinimide; dibenzoyl peroxide / tetrachloromethane View Scheme |
trityl chloride
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 2: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
2-<(trifluoromethanesulfonyl)oxy>benzonitrile
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 3 steps 1: 1.) Mg, I2; n-Bu3SnCl, 2.) Pd(PPh3)2Cl2, LiCl / 1.) THF, reflux, 30 min; THF, reflux, 20 h, 2.) DMF, 98 deg C, 24 h 2: 1.) NaN3, n-Bu3SnCl, 2.) NaOH / 1.) toluene, 115 deg C, 70 h, 2.) toluene, r.t., 3 h 3: NBS, AIBN / CCl4 / 3 h / Heating View Scheme |
2-(tetrazol-5-yl)-4'-methyl-1,1'-biphenyl
N-(triephenylmethyl)-5-<4'-(bromomethyl)-biphenyl-2-yl>tetrazole
Conditions | Yield |
---|---|
Multi-step reaction with 2 steps 1: toluene / 3 h / 20 °C 2: N-Bromosuccinimide; dihydrogen peroxide / dichloromethane / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: triethylamine / dichloromethane / 2 h / 0 °C / Reflux 2: dibenzoyl peroxide; N-Bromosuccinimide / tetrachloromethane / 3 h / Reflux View Scheme | |
Multi-step reaction with 2 steps 1: potassium hydroxide / methanol 2: bromine; acetic acid View Scheme |
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Molecular structure of 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole (CAS NO.124750-51-2) is:
Product Name: 5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole
CAS Registry Number: 124750-51-2
Molecular Formula: C33H25BrN4
Molecular Weight: 557.49
Melting Point: 152-155 °C
Surface Tension: 49.175 dyne/cm
Density: 1.282 g/cm3
Flash Point: 388.299 °C
Enthalpy of Vaporization: 104.977 kJ/mol
Boiling Point: 718.441 °C at 760 mmHg
Product Categories: Intermediatesof;Biphenyl & Diphenyl ether;Tetrazoles;API intermediates;(intermediates of candesartan cilexetil);Hypertension;Amines;Aromatics;Heterocycles;Intermediates
5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole (CAS NO.124750-51-2) is used as an intermediate in the synthesis of Losartan and Valsartan.
5-(4'-Bromomethyl-1,1'-biphenyl-2-yl)-1-triphenylmethyl-1H-tetrazole , its cas register number is 124750-51-2. It also can be called N-(Triphenylmethyl)-5-(4'-bromomethylbiphenyl-2-yl-)terazole .It is a off-white solid.