2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene

Base Information

• Chemical Name: 2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene
• CAS No.: 118629-88-2
• Molecular Formula: C₂₄H₂₁N₃O₅S
• Molecular Weight: 463.514
• Mol file: 118629-88-2.mol

Synonyms:2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene

Chemical Property of 2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of 2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene

There total 1 articles about 2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

2-(2,4-dinitrophenyl)-isoquinolinium chloride (33107-14-1) + phenylthioethylene (1822-73-7) → 2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene (118629-88-2)

Guidance literature:

With calcium carbonate; In methanol; at 25 - 40 ℃; for 72h;

DOI:10.1021/jo00266a019

Reference yield: 91.0%

2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene (118629-88-2) → 1(R*)-(dimethoxymethyl)-2(S*)-(phenylthio)-4(S*)-<(2,4-dinitrophenyl)amino>-1,2,3,4-tetrahydronaphthalene (118629-79-1)

Guidance literature:

With Dowex-50x8-400; In methanol; for 24h; Ambient temperature;

DOI:10.1021/jo00266a019

Reference yield:

2-(2,4-dinitrophenyl)-3(R*)-methoxy-9(S*)-(phenylthio)-1(S*),4(R*)-ethano-1,2,3,4-tetrahydronaphthalene (118629-88-2) → 1-naphthaldehyde (66-77-3)

Guidance literature:

With amberlyst-15; potassium carbonate; Yield given. Multistep reaction; 1.) THF, H₂O, 40 deg C, 24 h, 2.) THF, methanol, water, 50-60 deg C, 3 min;

DOI:10.1021/jo00266a019

upstream raw materials:

2-(2,4-dinitrophenyl)-isoquinolinium chloride

phenylthioethylene

Downstream raw materials:

1-naphthaldehyde

1(R*)-(dimethoxymethyl)-2(S*)-(phenylthio)-4(S*)-<(2,4-dinitrophenyl)amino>-1,2,3,4-tetrahydronaphthalene

1(R*)-(dimethoxymethyl)-2(S*)-(phenylthio)-4(S*)-amino-1,2,3,4-tetrahydronaphthalene