4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid

Base Information

Chemical Name:4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid
CAS No.:1446246-89-4
Molecular Formula:C₁₅H₁₅N₅O₆S
Molecular Weight:393.38
Hs Code.:

Synonyms:4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid

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Chemical Property of 4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid

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Technology Process of 4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid

There total 8 articles about 4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

: 1446246-84-9
3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide

: 1446246-89-4
4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid

Guidance literature:: 3-(4-nitrophenyl)-5-[(2-oxopyrrolidin-1-carbonyl)amino]isothiazol-4-carboxylic acid amide; With sodium hydroxide; at 20 ℃;

With hydrogenchloride; In water;

Reference yield:

: 605661-26-5
2-[amino(4-nitrophenyl)methylene]malononitrile

: 1446246-89-4
4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: O,O-Diethyl hydrogen phosphorodithioate / ethanol; water / 100 °C / Inert atmosphere

2.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

3.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

3.2: 20 °C

4.1: sulfuric acid / 1.83 h / 45 °C

4.2: Cooling with ice

5.1: sodium hydroxide / 20 °C

With sulfuric acid; dihydrogen peroxide; potassium carbonate; O,O-Diethyl hydrogen phosphorodithioate; sodium hydroxide; In tetrahydrofuran; ethanol; water; dimethyl sulfoxide;

Reference yield:

: 909028-96-2
3-amino-3-(4-nitrophenyl)-2-thioformamidoacrylonitrile

: 1446246-89-4
4-[({[4-(aminocarbonyl)-3-(4-nitrophenyl)isothiazol-5-yl]amino}carbonyl)amino]butanoic acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: dihydrogen peroxide / ethanol / 22 h / Inert atmosphere

2.1: potassium carbonate / tetrahydrofuran; dimethyl sulfoxide / 0.25 h / 20 °C

2.2: 20 °C

3.1: sulfuric acid / 1.83 h / 45 °C

3.2: Cooling with ice

4.1: sodium hydroxide / 20 °C

With sulfuric acid; dihydrogen peroxide; potassium carbonate; sodium hydroxide; In tetrahydrofuran; ethanol; dimethyl sulfoxide;