methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate

Base Information

Chemical Name:methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate
CAS No.:1354904-57-6
Molecular Formula:C₂₄H₁₉N₃O₅
Molecular Weight:429.432
Hs Code.:

Synonyms:methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate

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Chemical Property of methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate

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Technology Process of methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate

There total 7 articles about methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 274-47-5
imidazo[1,5-a]pyridine

: 1354904-57-6
methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate

Guidance literature:: Multi-step reaction with 3 steps

1.1: triethylamine / 1,2-dichloro-ethane / 4.5 h / 0 - 20 °C / Inert atmosphere

1.2: 20 - 80 °C / Inert atmosphere

2.1: N-Bromosuccinimide / dichloromethane / 2.5 h / Inert atmosphere

3.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,2-dimethoxyethane; water / 2 h / 90 °C / Inert atmosphere

3.3: 24 h / 20 °C

With N-Bromosuccinimide; potassium carbonate; triethylamine; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; dichloromethane; water; 1,2-dichloro-ethane; 3.1: Suzuki Coupling;

Reference yield:

: 944445-97-0
methyl 2-amino-5-[1-bromo-(imidazo[1,5-a]pyridine-3-yl carbonyl)]benzoate

: 99769-19-4
[3-(methoxycarbonyl)phenyl]boronic acid

: 74-88-4
methyl iodide

: 1354904-57-6
methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate

Guidance literature:: methyl 2-amino-5-[1-bromo-(imidazo[1,5-a]pyridine-3-yl carbonyl)]benzoate; [3-(methoxycarbonyl)phenyl]boronic acid; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In 1,2-dimethoxyethane; water; at 90 ℃; for 2h; Inert atmosphere;

With hydrogenchloride; In 1,2-dimethoxyethane; water;

methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;

Reference yield:

: 944445-97-0
methyl 2-amino-5-[1-bromo-(imidazo[1,5-a]pyridine-3-yl carbonyl)]benzoate

: 99768-12-4
4-methoxycarbonylphenylboronic acid

: 74-88-4
methyl iodide

: 1354904-57-6
methyl 2-amino-5-({1-[3-(methoxycarbonyl)phenyl]imidazo[1,5-a]pyridin-3-yl}carbonyl)benzoate

Guidance literature:: methyl 2-amino-5-[1-bromo-(imidazo[1,5-a]pyridine-3-yl carbonyl)]benzoate; 4-methoxycarbonylphenylboronic acid; With tetrakis(triphenylphosphine) palladium⁽⁰⁾; potassium carbonate; In 1,2-dimethoxyethane; water; at 90 ℃; for 2h; Inert atmosphere;

methyl iodide; With caesium carbonate; In N,N-dimethyl-formamide; at 20 ℃; for 24h;