tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate

Base Information

Chemical Name:tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate
CAS No.:1449476-01-0
Molecular Formula:C₁₆H₂₄BrN₃O₄
Molecular Weight:402.288
Hs Code.:

Synonyms:tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate

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Chemical Property of tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate

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Technology Process of tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate

There total 4 articles about tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 48068-25-3,1396972-31-8
(2S,3R)-2-((tert-butoxycarbonyl)amino)-3-methoxybutanoic acid

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1449476-01-0
tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate

Guidance literature:: (2S,3R)-2-((tert-butoxycarbonyl)amino)-3-methoxybutanoic acid; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -78 ℃; for 1h;

4-Bromo-benzene-1,2-diamine; In tetrahydrofuran; at -78 - 20 ℃; for 18h;

Reference yield: 96.0%

: 60538-19-4,79479-07-5,96099-84-2,113525-91-0
N-(tert-butoxycarbonyl)-l-threonine methyl ester

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1449476-01-0
tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate

Guidance literature:: N-(tert-butoxycarbonyl)-l-threonine methyl ester; With 4-methyl-morpholine; isobutyl chloroformate; In tetrahydrofuran; at -78 ℃; for 1h;

4-Bromo-benzene-1,2-diamine; In tetrahydrofuran; at -78 - 20 ℃; for 18h;
DOI:10.1016/j.bmc.2018.12.002

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 1449476-01-0
tert-butyl ((2S,3R)-1-((2-amino-4-bromophenyl)amino)-3-methoxy-1-oxobutan-2-yl)carbamate

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydrogencarbonate / tetrahydrofuran; water / 18 h / 0 - 20 °C

2.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -78 °C

2.2: 18 h / -78 - 20 °C

With 4-methyl-morpholine; sodium hydrogencarbonate; isobutyl chloroformate; In tetrahydrofuran; water;