4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate

Base Information

Chemical Name:4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate
CAS No.:1449473-81-7
Molecular Formula:CH₂O₂*C₁₈H₁₇FN₄O
Molecular Weight:370.383
Hs Code.:

Synonyms:4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate

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Chemical Property of 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate

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Technology Process of 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate

There total 8 articles about 4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 45.0%

: 64-18-6
formic acid

: tert-butyl ((1R,2R)-1-(5-(4-cyano-2-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-2-methoxypropyl)carbamate

: 1449473-81-7
4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate

Guidance literature:: tert-butyl ((1R,2R)-1-(5-(4-cyano-2-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-2-methoxypropyl)carbamate; With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

formic acid; In water;
DOI:10.1016/j.bmc.2018.12.002

Reference yield:

: tert-butyl ((1R,2R)-1-(5-(4-cyano-2-fluorophenyl)-1H-benzo[d]imidazol-2-yl)-2-methoxypropyl)carbamate

: 1449473-81-7
4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate

Guidance literature:: With trifluoroacetic acid; In dichloromethane; at 20 ℃; for 3h;

Reference yield:

: 1575-37-7
4-Bromo-benzene-1,2-diamine

: 1449473-81-7
4-(2-((1R,2R)-1-amino-2-methoxypropyl)-1H-benzo[d]imidazol-5-yl)-3-fluorobenzonitrile formate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine; isobutyl chloroformate / tetrahydrofuran / 1 h / -78 °C

1.2: 18 h / -78 - 20 °C

2.1: acetic acid / 90 h / 20 - 40 °C

3.1: [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium carbonate / tetrahydrofuran; water / 18 h / 60 °C / Inert atmosphere

4.1: trifluoroacetic acid / dichloromethane / 3 h / 20 °C

With 4-methyl-morpholine; [1,1'-bis(diphenylphosphino)ferrocene]dichloropalladium(II); sodium carbonate; acetic acid; trifluoroacetic acid; isobutyl chloroformate; In tetrahydrofuran; dichloromethane; water;