(+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

Base Information

Chemical Name:(+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine
CAS No.:459867-40-4
Molecular Formula:C₂₅H₂₅N₅O₃
Molecular Weight:443.505
Hs Code.:

Synonyms:(+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

Suppliers and Price of (+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

There total 7 articles about (+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

: 459867-39-1
(+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-chloropurine

: 459867-40-4
(+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

Guidance literature:: With ammonia; at 70 ℃; for 5h;
DOI:10.1016/S0040-4020(02)00287-9

Reference yield:

: 100-39-0
benzyl bromide

: 459867-40-4
(+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 63 percent / NaH / dimethylformamide / 0.67 h / 0 °C

2.1: 100 percent / 60 percent AcOH / 24 h / 50 °C

3.1: CAN / CH₂Cl₂ / 2 h / 20 °C

3.2: 66 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

4.1: 57 percent / PPh₃; DEAD / tetrahydrofuran / 16 h / 20 °C

5.1: 76 percent / TFA / CH₂Cl₂ / 16 h / 20 °C

6.1: 77 percent / methanolic anmmonia / 5 h / 70 °C

With ammonium cerium(IV) nitrate; ammonia; sodium hydride; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00287-9

Reference yield:

: 89291-76-9
(1S,4R,5S)-(-)-3-<(benzyloxy)methyl>-4,5-O-isopropylidene-2-cyclopenten-1-ol

: 459867-40-4
(+)-9-[(1R,2R,5S)-5-benzyloxy-3-(benzyloxy)methyl-2-hydroxy-cyclopent-3-en-1-yl]-6-aminopurine

Guidance literature:: Multi-step reaction with 6 steps

1.1: 63 percent / NaH / dimethylformamide / 0.67 h / 0 °C

2.1: 100 percent / 60 percent AcOH / 24 h / 50 °C

3.1: CAN / CH₂Cl₂ / 2 h / 20 °C

3.2: 66 percent / DIBAL-H / CH₂Cl₂ / 1 h / -78 °C

4.1: 57 percent / PPh₃; DEAD / tetrahydrofuran / 16 h / 20 °C

5.1: 76 percent / TFA / CH₂Cl₂ / 16 h / 20 °C

6.1: 77 percent / methanolic anmmonia / 5 h / 70 °C

With ammonium cerium(IV) nitrate; ammonia; sodium hydride; acetic acid; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4020(02)00287-9