2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid

Base Information

• Chemical Name: 2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid
• CAS No.: 22005-25-0
• Molecular Formula: C₁₅H₉NO₅
• Molecular Weight: 283.24
• Mol file: 22005-25-0.mol

Synonyms:2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid

Chemical Property of 2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

2-(4-Hydroxy-phenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylicacid ^*data from reagent suppliers

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Technology Process of 2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid

There total 1 articles about 2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

4-amino-phenol (123-30-8) + trimellitic Anhydride (552-30-7,145253-53-8) → 2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid (22005-25-0)

Guidance literature:

4-amino-phenol; trimellitic Anhydride; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 6h; Inert atmosphere;

In 1-methyl-pyrrolidin-2-one; toluene; at 120 ℃; for 10h; Dean-Stark;

DOI:10.4314/bcse.v32i3.11

Reference yield: 34.0%

1-amino-3-[4-(2-isopropoxyphenyl)piperazin-1-yl]propane (216252-71-0) + 2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid (22005-25-0) → 2-[4-hydroxyphenyl]-2,3-dihydro-N-[3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-1,3-dioxo-1H-isoindole-5-carboxamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 ℃;

DOI:10.1021/jm9905918

Reference yield: 23.0%

α-(aminomethyl)-4-[2-(1-methylethoxy)phenyl]-1-piperazineethanol (239807-63-7) + 2-(4-hydroxyphenyl)-1,3-dioxo-2,3-dihydro-1H-isoindole-5-carboxylic acid (22005-25-0) → 2-[4-hydroxyphenyl]-2,3-dihydro-N-[2-hydroxy-3-[4-[2-(1-methylethoxy)phenyl]-1-piperazinyl]propyl]-1,3-dioxo-1H-isoindole-5-carboxamide

Guidance literature:

With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; dmap; In dichloromethane; at 20 ℃; for 3h;

DOI:10.1021/jm9905918

upstream raw materials:

4-amino-phenol

trimellitic Anhydride

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