N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine

Base Information

• Chemical Name: N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine
• CAS No.: 109979-01-3
• Molecular Formula: C₅₃H₅₀N₈O₁₀
• Molecular Weight: 959.028

Synonyms:N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine

Chemical Property of N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine

Chemical Property:

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Useful:

Technology Process of N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine

There total 4 articles about N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

5'-azido-2',5'-dideoxy-N4-benzoylcytidine (74597-69-6) → N4-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N4-benzoyl-2',5'-dideoxycytidine (109979-01-3)

Guidance literature:

Multi-step reaction with 4 steps

1: H₂ / 10percent Pd/C / ethanol; dimethylformamide; acetic acid / 18.5 h / 1810.02 Torr

2: pyridine, Et₃N / 4 h

3: 67 percent / Et₃N / dimethylformamide / 2.5 h

4: Et₃N / dimethylformamide

With pyridine; hydrogen; triethylamine; palladium on activated charcoal; In ethanol; acetic acid; N,N-dimethyl-formamide;

DOI:10.1021/jo00228a010

Reference yield:

N4-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine (109979-00-2) → N4-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N4-benzoyl-2',5'-dideoxycytidine (109979-01-3)

Guidance literature:

Multi-step reaction with 2 steps

1: 67 percent / Et₃N / dimethylformamide / 2.5 h

2: Et₃N / dimethylformamide

With triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jo00228a010

Reference yield:

5'-amino-N4-benzoyl-2',5'-dideoxycytidine (109978-98-5) → N4-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N4-benzoyl-2',5'-dideoxycytidine (109979-01-3)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine, Et₃N / 4 h

2: 67 percent / Et₃N / dimethylformamide / 2.5 h

3: Et₃N / dimethylformamide

With pyridine; triethylamine; In N,N-dimethyl-formamide;

DOI:10.1021/jo00228a010

upstream raw materials:

p-nitrophenyl N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine 3'-carbonate

N-[1-((2R,4S,5R)-5-Aminomethyl-4-hydroxy-tetrahydro-furan-2-yl)-2-oxo-1,2-dihydro-pyrimidin-4-yl]-benzamide; compound with toluene-4-sulfonic acid

N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidine

5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine

Downstream raw materials:

4-nitrophenyl N⁴-benzoyl-2',5'-dideoxy-5'-(4''-monomethoxytrityl)aminocytidylyl-(3'-5''-carbamoyl)-5'-amino-N⁴-benzoyl-2',5'-dideoxycytidine 3'-carbonate

[(2R,3S,5R)-5-(4-Benzoylamino-2-oxo-2H-pyrimidin-1-yl)-3-hydroxy-tetrahydro-furan-2-ylmethyl]-carbamic acid (2R,3S,5R)-2-aminomethyl-5-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-tetrahydro-furan-3-yl ester; compound with toluene-4-sulfonic acid

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