cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

Base Information

Chemical Name:cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide
CAS No.:1258294-13-1
Molecular Formula:C₁₇H₁₅Cl₂N₃O₂
Molecular Weight:364.231
Hs Code.:

Synonyms:cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

Suppliers and Price of cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 2 raw suppliers

Chemical Property of cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

Safty Information:

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Hazard Codes:

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Technology Process of cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

There total 7 articles about cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1258298-00-8
N-(2-bromopyridin-4-yl)-2,6-dichlorobenzamide

: 81428-99-1
2-methylcyclopropanecarboxamide

: 1258294-16-4
2,6-dichloro-N-(2-((1R,2R)-2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

: 1258294-14-2
2,6-dichloro-N-(2-((1R,2S)-2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

: 1258294-13-1
cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

: 1258294-15-3
2,6-dichloro-N-(2-((1S,2S)-2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

Guidance literature:: With caesium carbonate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 160 ℃; for 2h; Microwave irradiation; Inert atmosphere;

Reference yield:

: 4659-45-4
2,6-Dichlorobenzoyl chloride

: 1258294-14-2
2,6-dichloro-N-(2-((1R,2S)-2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

: 1258294-13-1
cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

: C₁₇H₁₅Cl₂N₃O₂

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydride / N,N-dimethyl-formamide / 0 °C

2: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 2 h / 160 °C / Inert atmosphere; Microwave irradiation

3: triethylamine / hexane; ethanol / Resolution of racemate

With tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; sodium hydride; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; hexane; N,N-dimethyl-formamide;
DOI:10.1021/jm400266t

Reference yield:

: 29555-02-0
2-methyl-cyclopropanecarboxylic acid

: 1258294-14-2
2,6-dichloro-N-(2-((1R,2S)-2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

: 1258294-13-1
cis-2,6-dichloro-N-(2-(2-methylcyclopropanecarboxamido)pyridin-4-yl)benzamide

: C₁₇H₁₅Cl₂N₃O₂

Guidance literature:: Multi-step reaction with 4 steps

1: triethylamine / acetone / 1.5 h / 0 °C

2: ammonium hydroxide / 3 h / 20 °C

3: tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; caesium carbonate / 1,4-dioxane / 2 h / 160 °C / Inert atmosphere; Microwave irradiation

4: triethylamine / hexane; ethanol / Resolution of racemate

With ammonium hydroxide; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; caesium carbonate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; ethanol; hexane; acetone;
DOI:10.1021/jm400266t