29555-02-0

Usage

Uses

Used in Pharmaceutical Industry:
2-METHYLCYCLOPROPANECARBOXYLIC ACID is used as a chemical intermediate for the preparation of Spirocyclic Dihydroindols, which are HPK1 inhibitors. These inhibitors play a crucial role in the development of novel therapeutic strategies for various diseases, including cancer and autoimmune disorders, by modulating the activity of the hematopoietic progenitor kinase 1 (HPK1).
Used in Natural Product Synthesis:
In the field of natural product synthesis, 2-METHYLCYCLOPROPANECARBOXYLIC ACID serves as a key component in the synthesis of curacin A, a complex natural product with potential applications in drug discovery and development. Curacin A has been studied for its cytotoxic and antimitotic properties, making it a valuable compound for further research and potential therapeutic applications.

InChI:InChI=1/C5H8O2/c1-3-2-4(3)5(6)7/h3-4H,2H2,1H3,(H,6,7)/p-1/t3-,4-/m1/s1

Upstream product

• 6077-72-1 2-methylcyclopropanemethanol 
• 867-13-0 diethoxyphosphoryl-acetic acid ethyl ester 
• 75-56-9 methyloxirane 
• 39763-88-7 2-(2-methyl-cyclopropyl)-furan 
• 10180-00-4 2-methylcyclopropane-1,1-dicarboxylic acid 
• 143541-56-4 2-methylcyclopropylglyoxylsaeure 
• 7722-84-1 dihydrogen peroxide 
• 70786-82-2 ethyl 4-chloropentanoate 
• 623-73-4 diazoacetic acid ethyl ester 
• 187737-37-7 propene 
• 1192-08-1 3-methylcyclobutan-1-one 
• 21003-35-0 cis-2-methylcyclopropyl-1-methanol 
• 20913-25-1 2-Methylcyclopropancarbonsaeureethylester 
• 108-29-2 5-methyl-dihydro-furan-2-one 

Downstream Products

• 42274-66-8 2-methylcyclopropanecarboxylic acid chloride 
• 68979-89-5 2-methylcyclopropan-1-amine 
• 1016807-38-7 2-Methyl-cyclopropylisocyanat 
• 64190-48-3 dihydro-4-methyl-2(3H)-furanone 
• 108-29-2 5-methyl-dihydro-furan-2-one 
• 192644-20-5 2-methylcyclopropanecarboxylic acid N-methoxy-N-methyl-amide 
• 192644-21-6 (3,5-dimethylphenyl)-(2-methylcyclopropyl)methanone 
• 81428-99-1 2-methylcyclopropanecarboxamide 
• 1033041-17-6 C₂₁H₁₈FN₅O₂ 
• 1374675-87-2 2-Chloro-4-[(S)-3-(2-chloro-4-pyrazol-1-yl-benzenesulfonyl)-pyrrolidin-1-yl]-5,7-dihydro-pyrrolo[3,4-d]pyrimidine-6-carbaldehyde 
• 1610704-14-7 phenyl (1R,2S)-2-methylcyclopropanecarboxylate 
• 1610704-15-8 phenyl (1S,2R)-2-methylcyclopropanecarboxylate 
• 10487-86-2 (1R,2R)-2-methylcyclopropanecarboxylic acid 
• 959774-49-3 (1S,2S)-N-benzyl-2-methylcyclopropane-1-carboxamide 

Relevant academic research and scientific papers

SUBSTITUTED CARBOXAMIDES

This application relates to a substituted carboxamide compound of formula I, or a pharmaceutically acceptable salt thereof, as defined herein, a pharmaceutical composition thereof, and its use in treating pain.

N-Cyclopropylisoindolines

Compounds of the general formula: STR1 in which A is a benzene ring or a carbocyclic aromatic group consisting of two or three fused benzene rings, the group A being linked to the nitrogen containing ring at two adjacent carbon atoms and the benzene ring or each benzene ring optionally carrying one or more substituents which may be the same or different, and may be alkyl, aryl, halo, hydroxy, acyloxy or alkoxy, or two adjacent positions in a ring may be substituted so as to form a methylene dioxy group (--O--CH2 --O--); R1 and R2 which may be the same or different, each represent hydrogen; an alkyl group which contains 1 to 6 carbon atoms and which may be substituted; a hydroxycarbonyl or an alkoxycarbonyl group; and one of R3 and R4 represents hydrogen, an alkyl group which contains 1 to 6 carbon atoms and which may be substituted, or a hydroxy, alkoxy, hydroxycarbonyl or alkoxycarbonyl group and the other of R3 and R4 represents hydrogen, or a non-toxic physiologically acceptable salt or bioprecursor thereof. These compounds are useful in the treatment of patients suffering from depression.

Cyanovinyl cyclopropanecarboxylic acids

The invention relates to novel substituted cyanovinyl cyclopropanecarboxylic acids and method of preparation thereof. The cyanovinyl cyclopropanecarboxylic acids are useful intermediates for the preparation of novel insecticidal-acaricidal pyrethroids.