5-Aminoisophthalic acid monomethyl ester

Base Information

• Chemical Name: 5-Aminoisophthalic acid monomethyl ester
• CAS No.: 28179-47-7
• Molecular Formula: C9H9NO4
• Molecular Weight: 195.175
• Hs Code.: 2942000000
• Mol file: 28179-47-7.mol

Synonyms:Monomethyl 5-Amino Isophthalate;1,3-Benzenedicarboxylicacid, 5-amino-, monomethyl ester (9CI);Isophthalic acid, 5-amino-, monomethylester (8CI);3-Amino-5-methoxycarbonylbenzoic acid;3-Carbomethoxy-5-aminobenzoic acid;5-Aminobenzene-1,3-dicarboxylic acidmonomethyl ester;Monomethyl 5-aminoisophthalate;

Chemical Property of 5-Aminoisophthalic acid monomethyl ester

Chemical Property:

• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.609
• Boiling Point: 440.418 °C at 760 mmHg
• Flash Point: 220.157 °C
• PSA: 89.62000
• Density: 1.373 g/cm³
• LogP: 1.33480
• Storage Temp.: 2-8°C(protect from light)

Purity/Quality:

98.0%min ^*data from raw suppliers

5-AminoisophthalicAcidMonomethylEster ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-Aminoisophthalic acid monomethyl ester

There total 1 articles about 5-Aminoisophthalic acid monomethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester (1955-46-0) → 5-aminoisophthalic acid monomethyl ester (28179-47-7)

Guidance literature:

With hydrogen; palladium dihydroxide; In methanol; for 5h; under 2585.81 Torr;

Reference yield: 97.0%

5-aminoisophthalic acid monomethyl ester (28179-47-7) → 3-bromo-5-(methoxycarbonyl)benzoic acid (161796-10-7)

Guidance literature:

With n-Butyl nitrite; copper(ll) bromide; In acetonitrile; at 0 - 20 ℃; for 3.5h;

Reference yield: 56.0%

N-(1-ethoxyethylidene)-2-aminooxyacetic acid N-hydroxysuccinimidyl ester (960607-67-4) + 5-aminoisophthalic acid monomethyl ester (28179-47-7) → 3-(2-(1-ethoxyethylideneaminooxy)acetamido)-5-(methoxycarbonyl)benzoic acid

Guidance literature:

With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 20 ℃; for 12h;

DOI:10.1039/c3ob40086g

upstream raw materials:

5-nitro-1,3-benzenedicarboxylic acid, monomethyl ester

Downstream raw materials:

3-bromo-5-(methoxycarbonyl)benzoic acid

3-iodo-5-(methoxycarbonyl)benzoic acid

3-[(3-Chlorophenyl)carbonylamino]-5-(methoxycarbonyl)benzoic Acid

3-chloro-5-(methoxycarbonyl)benzoic acid

Refernces

• 1、 Fujimoto, Noriko,Matsumura, Mio,Azumaya, Isao,Nishiyama, Shizuka,Masu, Hyuma,Kagechika, Hiroyuki,Tanatani, Aya. "Molecular chirality and chiral capsule-type dimer formation of cyclic triamides via hydrogen-bonding interactions". supporting information; experimental part. p. 4809 - 4811. Retrieved 2012/06/30.
• 2、 Wu, Yong-Jin,Zhang, Yunhui,Good, Andrew C.,Burton, Catherine R.,Toyn, Jeremy H.,Albright, Charles F.,Macor, John E.,Thompson, Lorin A.. "Synthesis and SAR of hydroxyethylamine based phenylcarboxyamides as inhibitors of BACE". scheme or table. p. 2654 - 2660. Retrieved 2010/01/16.