3-CHLORO-5-(METHOXYCARBONYL)BENZOIC ACID

Base Information

• Chemical Name: 3-CHLORO-5-(METHOXYCARBONYL)BENZOIC ACID
• CAS No.: 153203-57-7
• Molecular Formula: C9H7 Cl O4
• Molecular Weight: 214.605
• Hs Code.: 2917399590
• Mol file: 153203-57-7.mol

Synonyms:1,3-Benzenedicarboxylicacid, 5-chloro-, monomethyl ester (9CI); 5-Chloroisophthalic acid monomethylester

Chemical Property of 3-CHLORO-5-(METHOXYCARBONYL)BENZOIC ACID

Chemical Property:

• Vapor Pressure: 3.29E-06mmHg at 25°C
• Refractive Index: 1.57
• Boiling Point: 372.5°C at 760 mmHg
• Flash Point: 179.1°C
• PSA: 63.60000
• Density: 1.413g/cm³
• LogP: 1.82480

Purity/Quality:

97% ^*data from raw suppliers

5-ChloroisophthalicAcidmonomethylester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 3-CHLORO-5-(METHOXYCARBONYL)BENZOIC ACID

There total 3 articles about 3-CHLORO-5-(METHOXYCARBONYL)BENZOIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

1,3-dimethyl 5-chlorobenzene-1,3-dicarboxylate (20330-90-9) → 3-chloro-5-(methoxycarbonyl)benzoic acid (153203-57-7)

Guidance literature:

With methanol; sodium hydroxide; In tetrahydrofuran; at 25 ℃; for 16h;

Reference yield: 47.0%

5-aminoisophthalic acid monomethyl ester (28179-47-7) → 3-chloro-5-(methoxycarbonyl)benzoic acid (153203-57-7)

Guidance literature:

With n-Butyl nitrite; copper dichloride; In acetonitrile; at 0 - 20 ℃; for 2h;

Reference yield:

→ 3-chloro-5-(methoxycarbonyl)benzoic acid (153203-57-7)

Guidance literature:

upstream raw materials:

1,3-dimethyl 5-chlorobenzene-1,3-dicarboxylate

5-aminoisophthalic acid monomethyl ester

Downstream raw materials:

methyl 3-chloro-5-(hydroxymethyl)benzoate

Methyl 3-[(tert-butoxycarbonyl)amino]-5-chlorobenzoate

methyl 5-chloro-3-aminobenzoate-trifluoroacetate

methyl 3-carbamoyl-5-chlorobenzoate