(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

Base Information

Chemical Name:(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate
CAS No.:1255860-34-4
Molecular Formula:C₂₄H₃₂N₃O₁₀P
Molecular Weight:553.506
Hs Code.:

(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

Synonyms:(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

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Chemical Property of (2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

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Technology Process of (2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

There total 15 articles about (2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (2S)-butyl 2-((chloro(phenoxy)phosphoryl)amino)propanoate

: 1255860-33-3
1-[(4R,5R,7R,8R)-8-hydroxy-7-(hydroxyl-methyl)-1,6-dioxaspiro[3.4]octan-5-yl]pyrimidine-2,4(1H,3H)-dione

: 1255860-34-4
(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; dichloromethane; for 23h;

Reference yield:

: 885592-69-8
(2S,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxydihydrofuran-3(2H)-one

: 1255860-34-4
(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 7 steps

1.1: diethyl ether; tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere

2.1: triethylamine / dmap / dichloromethane / 120 h

3.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1 h / Reflux

3.2: 2.5 h / 20 °C / Reflux

4.1: osmium(VIII) oxide; sodium periodate / water; tert-butyl alcohol; tetrahydrofuran / 2 h / 20 °C

4.2: 20 °C

5.1: methanesulfonyl chloride; pyridine / pyridine / 2 h / 20 °C

5.2: 2 h / 20 °C

6.1: hydrogen / palladium(II) hydroxide / methanol / 20 °C

7.1: 1-methyl-1H-imidazole / dichloromethane; tetrahydrofuran / 23 h

With pyridine; 1-methyl-1H-imidazole; sodium periodate; osmium(VIII) oxide; N,O-bis-(trimethylsilyl)-acetamide; hydrogen; methanesulfonyl chloride; triethylamine; dmap; palladium(II) hydroxide; In tetrahydrofuran; pyridine; methanol; diethyl ether; dichloromethane; water; acetonitrile; tert-butyl alcohol;

Reference yield:

: 1255860-30-0
1-((2R,3R,4R,5R)-3-allyl-4-(benzyloxy)-5-(benzyloxymethyl)-3-hydroxytetra-hydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

: 1255860-34-4
(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

Guidance literature:: Multi-step reaction with 4 steps

1.1: osmium(VIII) oxide; sodium periodate / water; tert-butyl alcohol; tetrahydrofuran / 2 h / 20 °C

1.2: 20 °C

2.1: methanesulfonyl chloride; pyridine / pyridine / 2 h / 20 °C

2.2: 2 h / 20 °C

3.1: hydrogen / palladium(II) hydroxide / methanol / 20 °C

4.1: 1-methyl-1H-imidazole / dichloromethane; tetrahydrofuran / 23 h

With pyridine; 1-methyl-1H-imidazole; sodium periodate; osmium(VIII) oxide; hydrogen; methanesulfonyl chloride; palladium(II) hydroxide; In tetrahydrofuran; pyridine; methanol; dichloromethane; water; tert-butyl alcohol;