butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

Base Information

Chemical Name:butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate
CAS No.:1375074-52-4
Molecular Formula:C₂₄H₃₂N₃O₁₀P
Molecular Weight:553.506
Hs Code.:

Synonyms:butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

Suppliers and Price of butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

There total 16 articles about butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 1255860-34-4
(2S)-butyl-2-(((((4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxa-spiro[3.4]octan-7-yl)-methoxy)(phenoxy)phosphoryl)amino)propanoate

: 1375074-52-4
butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

Guidance literature:: With MultigramII Supercritical Fluid Chromatography system; In ethanol; carbon dioxide; isopropylamine; at 25 ℃; under 75007.5 Torr; Resolution of racemate;

Reference yield:

: (2S)-butyl 2-((chloro(phenoxy)phosphoryl)amino)propanoate

: 1255860-33-3
1-[(4R,5R,7R,8R)-8-hydroxy-7-(hydroxyl-methyl)-1,6-dioxaspiro[3.4]octan-5-yl]pyrimidine-2,4(1H,3H)-dione

: 1375074-52-4
butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

: 1375071-01-4
butyl N-[(S)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydro-pyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)-phosphoryl]-L-alaninate

Guidance literature:: With 1-methyl-1H-imidazole; In tetrahydrofuran; dichloromethane; at 25 ℃; for 23h;

Reference yield:

: 885592-69-8
(2S,4R,5R)-4-(benzyloxy)-5-((benzyloxy)methyl)-2-methoxydihydrofuran-3(2H)-one

: 1375074-52-4
butyl N-[(R)-{[(4R,5R,7R,8R)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)-8-hydroxy-1,6-dioxaspiro[3.4]oct-7-yl]methoxy}(phenoxy)phosphoryl]-L-alaninate

Guidance literature:: Multi-step reaction with 8 steps

1.1: tetrahydrofuran / 6 h / -78 - 20 °C / Inert atmosphere

2.1: triethylamine / dmap / dichloromethane / 120 h

3.1: N,O-bis-(trimethylsilyl)-acetamide / acetonitrile / 1 h / Reflux

3.2: 2.5 h / 20 °C / Reflux

4.1: osmium(VIII) oxide; sodium periodate / water; tert-butyl alcohol; tetrahydrofuran / 2 h / 20 °C

4.2: 20 °C

5.1: methanesulfonyl chloride; pyridine / 2 h / 20 °C

5.2: 2 h / 20 °C

6.1: hydrogen / palladium(II) hydroxide / methanol / 20 °C

7.1: 1-methyl-1H-imidazole / dichloromethane; tetrahydrofuran / 23 h

8.1: Multigram_.(TM).II Supercritical Fluid Chromatography system / ethanol; carbon dioxide; isopropylamine / 25 °C / 75007.5 Torr / Resolution of racemate

With pyridine; 1-methyl-1H-imidazole; sodium periodate; osmium(VIII) oxide; N,O-bis-(trimethylsilyl)-acetamide; hydrogen; methanesulfonyl chloride; triethylamine; dmap; palladium(II) hydroxide; In tetrahydrofuran; methanol; ethanol; dichloromethane; carbon dioxide; water; isopropylamine; acetonitrile; tert-butyl alcohol;