p-Toluidine hydroiodide

Base Information

• Chemical Name: p-Toluidine hydroiodide
• CAS No.: 90263-57-3
• Molecular Formula: C₇H₉N*HI
• Molecular Weight: 235.068
• Mol file: 90263-57-3.mol

Synonyms:p-Toluidine hydroiodide

Chemical Property of p-Toluidine hydroiodide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of p-Toluidine hydroiodide

There total 2 articles about p-Toluidine hydroiodide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

iodobenzene (591-50-4) + carbon monoxide (201230-82-2) + p-toluidine (106-49-0,12221-03-3) → N-(4-methylphenyl)benzamide (582-78-5) + p-Toluidine hydroiodide (90263-57-3)

Guidance literature:

bis(triphenylphosphine)nickel⁽⁰⁾ dicarbonyl; In benzene; at 180 ℃; for 6h; under 30400 Torr; Yield given;

DOI:10.1016/0022-328X(87)80354-6

Reference yield:

p-toluidine (106-49-0,12221-03-3) + methyl iodide (74-88-4) → p-Toluidine hydroiodide (90263-57-3) + N-methyl-p-toluidine; hydriodide (13330-14-8) + trimethyl-p-tolylammonium iodide (6140-15-4) + 4-Methyl-N,N-dimethylanilin-hydrojodid (13330-16-0)

Guidance literature:

In acetonitrile;

DOI:10.1016/j.mencom.2019.07.028

Reference yield: 85.0%

p-Toluidine hydroiodide (90263-57-3) + 2,4,6-Trioxoperhydropyrimidine-5-spirocyclopropane-2',2',3',3'-tetracarbonitrile → 5-(α,α-Dicyano-4-methylbenzyl)perhydropyrimidine-2,4,6-trione

Guidance literature:

In isopropyl alcohol;

upstream raw materials:

iodobenzene

carbon monoxide

p-toluidine

methyl iodide

Downstream raw materials:

Dimethyl-p-toluidine

N,N-diethyl-p-toluidine

p-toluidino-ethenetricarbonitrile

Refernces

• 1、 Balybin, Alexei G.,Panov, Yuri M.,Erkhova, Ludmila V.,Lemenovskii, Dmitry A.,Krut'ko, Dmitry P.. "Selective Hofmann alkylation of aromatic-aliphatic diamines in the presence of carbon dioxide". . p. 438 - 440. Retrieved 2019/08/20.